Endocrine Abstracts

Introduction: Maternal obesity is associated with an increased risk of gestational diabetes, large for gestational age (LGA) newborns, preterm delivery, congenital malformations, and fetal death. On the other hand, bariatric surgery before pregnancy is associated with a reduction of obesity-associated complications, but also with an increased risk of small for gestational age (SGA) newborns, fetal growth restriction and micronutrient deficiencies during pregnancy.<p class=...

Introduction: Amyloidosis is a disease characterized by the accumulation of an amorphous proteinaceous material, known as amyloid, in various organs and tissues of the body. Amyloid goiter is a remarkably rare pathologic condition due to thyroid massive amyloid infiltration of amyloid light chain (primary) or amyloid A (secondary amyloidosis) proteins. Case: 54 year-old male, with known history of chronic tophaceous gout medicated with anakinra and predn...

Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of Cushing’s syndrome (CS). It is a highly heterogeneous disease with multiple adrenal macronodules and variable levels of cortisol excess. The pathogenesis is complex and different mechanisms such as aberrant hormone receptors, local production of ACTH in adrenal tissues and genetic mutations have been identified. The approach is not well established. Nine patients with PBMAH who are currently fol...

Introduction: Black adrenal adenomas are rare and benign. They are named after their black appearance, due to lipofuscin pigment. Most frequently black adenomas are associated with ACTH-independent Cushing’s syndrome. They can also cause primary hyperaldosteronism or be nonfunctioning. Unlike most other adrenal adenomas, black adenomas exhibit high Hounsfield units (>30) on CT, and high standard uptake value on FDG-PET.Case presentation: A 67-ye...

Introduction: In patients with ACTH-dependent Cushing Syndrome, differentiating between pituitary and ectopic sources can be challenging. Noninvasive testing can be performed, but bilateral inferior petrosal sinus sampling (BIPSS) remains the gold standard. In the last years however, novel imaging modalities, namely 3T-MRI with 3-dimensional spoiled gradient-echo sequence and 68Ga-tagged CRH combined with positron emission tomography, have been proposed as alternatives.<p ...

Introduction: People living with human immunodeficiency virus (HIV) are at increased risk of developing metabolic disorders, such as obesity, dyslipidemia, insulin resistance, diabetes and hypertension; which may also be associated with hypercortisolism. Due to the similarity between the metabolic changes present in these two clinical situations, several studies have evaluated whether HIV-infected patients have increased levels of cortisol, but the results are not consensual. ...

The ingestion of high-fat diet has been considered a crucial factor in the genesis of subclinical systemic inflammation and insulin resistance. The resistance training (RTr) can be an effective tool for the prevention and treatment of immune-metabolic disorders through physiological and morphological adaptations. The purpose of the present study was to analyze the effects of RTr and cessation of training on muscle inflammation and expression of genes related to glucose metabol...

Introduction: Pheochromocytoma is one of the major secondary causes of hypertension. The classic triad of pheochromocytoma symptoms of headache, sweating and tachycardia is not present in a high percentage of patients and is sometimes diagnosed as incidentaloma or atypical presentations.Case report: The authors present a 56-year-old man, with no known diseases, referred to Endocrinology evaluation by incidentaloma of the right adrenal gland, from the Pne...

Objectives: To study the association of serotonin transporter gene (SLC6A4) polymorphism 5HTTVNTR and serotonin receptor 2A polymorphism 5HT2A_T102C with bone mineral density and metabolic parameters of bone remodelling.Materials and methods: BMD (g/cm2) was measured by DEXA in 105 post-menopausal women: 35 with normal BMD (age=58.30±1.33 years; BMI=28.18 [19.13-39.87] kg/m2) and 70 with osteoporosis (age=68.30±1.09 years; BMI=28.90 ...

Objectives: To study the association of Beta-2 adrenergic receptor (ADRB2) gene polymorphism Arg16Gly with bone mineral density and metabolic parameters of bone remodelling.Materials and methods: BMD (g/cm2) was measured by DEXA in 105 post-menopausal women: 35 with normal BMD (age=58.30±1.33 years; BMI=28.18 [19.13-39.87] kg/m2) and 70 with osteoporosis (age=68.30±1.09 years; BMI=28.90 [20.78-43.86] kg/m2). Met...