Endocrine Abstracts

Introduction: It is universally accepted that calcitonin (CT), a hormone secreted by the parafollicular cells of the thyroid, is a specific, sensitive and early marker of Medullary Thyroid Carcinoma (CMT), with higher diagnostic accuracy than fine needle aspiration biopsy(FNAB). However, the routine measurement of serum CT during assessment of nodular thyroid disease (NTD) remains controversial due to rarity of this cancer and possible false positive results.<p class="abst...

Introduction: Medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) are two distinct neoplasms originating from follicular and parafolicular-C cells, respectively. These pathologies have always been considered different from each other in terms of their incidence, their cell origin and their histopathological features. Concurrent occurrence of MTC and PTC in the same patient is an unusual event and its occurrence as true mixed medullary-follicular-derived car...

Background: The association between isolated office hypertension (IOH) and masked hypertension (MH) with left ventricular hypertrophy (LVH) and diastolic dysfunction cannot be the same, determining different increased cardiovascular risk.Aims: To evaluate the prevalence of MH and IOH in treated hypertensive patients with type 2 diabetes and their association with LVH and diastolic dysfunction.Methods: A cross-sectional study was co...

Introduction: Precocious pubarche is defined as pubic hair onset before age eight in girls and age nine in boys. In 5–20% of cases the cause is late-onset congenital adrenal hyperplasia (LO-CAH), which is due mainly to non-classic 21-hydroxylase deficiency. If not promptly diagnosed, it can lead to accelerated bone maturation, short final height, and in adulthood to severe acne, hirsutism and infertility.Case report: Adolescent male, 15 years-old, h...

Aim: To evaluate the prevalence of goiter and nodular disease in patients with class III obesity, and also correlate the findings with serum insulin, leptin and HOMA-IR.Methods: A cross-sectional study with thyroid ultrasound and serum glucose, insulin, leptin and TSH was performed with obese patients and a control group without known thyroid diseases, matched for age and sex, but with BMI of <25 kg/m2.Results: Twent...

Introduction: Amiodarone-induced thyrotoxicosis(AIT) is a condition fraught with difficulties from the diagnostic and therapeutic standpoints. It can be developed precociously or years after the beginning amiodarone uptake and after its suspension. AIT is subdivided in three different forms. Type 1 is developed in subjects with underlying thyroid disease, being caused by an exacerbation by iodine load of thyroid autonomous function. Type 2 is a form of destructive thyroiditis ...

Introduction: Recently, noninsulinoma pancreatogenous hypoglycaemia syndrome (NIPHS) has been described following Roux-en-Y Gastric Bypass Surgery in morbidly obese patients. It has been proposed that hypoglycaemia might be a consequence of a failure to adaptively decrease insulin secretion after surgery. The authors present a case of a morbidly obese patient with severe hypoglycaemias beginning 3 months after gastric banding surgery.Case report: A 60-ye...

Introduction: Obesity has been associated with increased androgenicity in women, however there are conflicting data on this subject. Objectives: To determine whether any androgen is independently related to body mass index (BMI), waist-to-hip ratio (WHR) or age. To access if there is an association between elevated plasma androgen levels and the presence of either morbid obesity or metabolic syndrome (MS).Design and Methods: A total of 148 obese women we...

A positive association between thyrotropin (TSH) secretion and body-mass index (BMI) was previously reported. There are many studies concerning thyroid function in obesity, and some of them describe higher TSH levels in obese subjects.Evaluation of the hypothyroidism prevalence in a sample of obese women in their first obesity appointment at Hospital São João.Anthropometric variables and serum levels of TSH, free triiodot...

IntroductionThe most cost-effective, minimally invasive and accurate tool to discriminate benign from malignant thyroid nodules is a fine-needle aspiration biopsy (FNAB). However, 2%–24% of FNABs provide non-diagnostic results, which are a clinical challenge, particularly when this result is recurrent.AimTo determine the predictive factors for recurrent non-diagnostic FNAB in thyroid nodules.<p class...