Endocrine Abstracts

Introduction: Secondary causes of diabetes refer to a category in which diabetes is associated with other diseases. They are thought to constitute less than 2% of the total cases of diabetes.Case report: A 56 year-old caucasian man, with no relevant medical history, presented to the Emergency Department with fatigue, polyuria, polydipsia, polyphagia and involuntary weight loss (6 kg in two weeks). He was hemodynamically stable and exhibited a glycaemia o...

Introduction: Turner syndrome is one of the most common human chromosomopathy and represents an important cause of short stature and ovarian insufficiency. It is caused by total or partial loss of X-chromosome and its prevalence is about 1 in 2000–2500 live female births.Objectives: To review the patients with TS followed in a Paediatric Endocrinology Unit since 1999.Methods: A retrospective study regarding diagnosis, course, ...

Introduction: Hypopituitarism is a clinical syndrome of deficiency in growth hormone (GHD) production, which can occur isolated or associated with others pituitary defects. GHD has an incidence of 1:4000 to 1:10 000. It may be idiopathic, congenital or acquired.Purpose: Characterize the paediatric population with GHD followed at the Paediatric Endocrinology Unit of our centre and compare the clinical presentation and treatment response of the patients wi...

Introduction: The endocrine system is often affected in the course of HIV infection. However, hypopituitarism and diabetes insipidus are uncommon disorders in these patients and have been related to drugs, infections of the central nervous system and neoplastic infiltration, in extremely rare cases.Case report: We present a case of a 42-year-old man with HIV infection known since 2005, but undergoing antiretroviral therapy only since 2010 (emtricitabine/...

Introduction: 131I-iodide therapy (RIT) is an important treatment modality for patients with differentiated thyroid carcinoma (DTC). However, despite the overall excellent outcome, some DTC patients with poor prognosis may require multiple doses of radioactive iodine.Aim: The purpose of our study was to evaluate the efficacy of cumulative doses (CDs) of RIT in metastatic DTC patients.Material and methods: A retrospective study was ...

Introduction: The incidence of glucose metabolism alterations during the follow-up of surgically treated insulinomas is largely unknown. Our aim was to evaluate the incidence, and the clinical characteristics, of diabetes and prediabetes in this population.Methods: We retrospectively analyzed the cases diagnosed as insulinomas in a Central Hospital in Portugal in the period between January 1980 and December 2015.Results: We identif...

Introduction: Propylthiouracil is a drug used in the treatment of hyperthyroidism and autoimmunity phenomena have been described as a side effect of its use. Despite anti-neutrophil cytoplasmic antibodies (anca) positivity is frequent in patients treated with propylthiouracil, the occurrence of clinically evident vasculitis is rare.Case report: A 65-year-old woman, diagnosed with hyperthyroidism 2 years ago and treated with propylthiouracil (50+...

Introduction: Insulinomas are pancreatic endocrine tumors originating in the beta cells, characterized by hypoglycemia resulting from insulin hypersecretion.Objectives: To characterize the demography, the clinical features, imagiological findings and pathological evaluation of the cases of insulinomas identified in the previous 35 years at São João Hospital.Methods: We retrospectively analyzed the cases diagnosed as insul...

Coupling the release of pituitary hormones to the developmental stage of the oocyte is essential for female fertility. It requires estrogen to have simultaneous positive and negative feedback effects on spatially-distinct regions of the hypothalamus. However, the mechanistic basis for this differential effect is not known. We have found that negative-feedback is mediated by the nuclear receptor Dax1, which is present in the arcuate hypothalamic nucleus and serves as a ligand-d...

Introduction: HIV infection and combined antiretroviral therapy (cART) have been associated with lipodistrophy and changes in body composition. However, there are few studies on body composition evolution of HIV-infected patients, under cART.Aims: To evaluate the evolution of body composition in HIV-1 infected patients under cART over 5 years.Methods: Retrospective, observational study in a cohort of HIV-infected patients on cART. ...