Endocrine Abstracts

Introduction: Maturity onset diabetes of the young (MODY) accounts for 1-2% of all forms of diabetes mellitus (DM). As classic criteria that lead to its suspicion have low sensitivity, patients are often misdiagnosed with type 1 or type 2 DM. Correct classification of this type of diabetes becomes essential for proper management of the disease. Our objective was to describe clinical features of patients with MODY diagnosed at our institution.Methods: We ...

Introduction: Gastroparesis is defined by a delayed gastric emptying without mechanical obstruction. It can be a debilitating complication of diabetes that is poorly understood and has limited therapeutic options.Case reports: 1st case - We report the case of a 34-year-old woman with type 1 diabetes mellitus (T1DM) with diabetic nephropathy and gastroparesis, and a reasonable glycaemic control...

Introduction: Diabetes mellitus (DM) is a chronic disease that requires continuous medical care. Health care providers should adopt approaches that improve patient outcomes and adherence.Aims: To evaluate the adherence to Endocrinology ambulatory follow-up after elective hospital admission for decompensated DM and to determine the relationship between adherence and therapeutic success after discharge.Methods: Retrospective study of...

Introduction: Familial partial lipodystrophy (FPL) is an autosomal dominant disease characterized by selective loss of subcutaneous fat from the extremities and gluteal region, with lipohypertrophy of the face, neck and trunk. It is usually tightly linked with severe metabolic complications. FPL type 3 results from peroxisome proliferator-activated receptor gamma (PPARG) mutations.Case presentations: Fifty three-year-old woman, referred to endocrinology ...

Introduction: Diabetic gastroparesis (DGP) is defined by delayed gastric emptying in the absence of mechanical obstruction caused by autonomic neuropathy. Only 5% of type 1 and 1% of type 2 diabetic patients combine the delay of gastric emptying with typical gastroparesis symptoms. This entity is usually identified in patients with least 10 years of diabetes evolution and is presented typically in the 4th to 5th decades of life in type 1 diabetes mellitus (T1DM). It is associa...

Introduction: Type 1 diabetes (T1D) is an important endocrine disease in the pediatric age group. The shift from pediatrics to adult health care providers is a critical period for adolescents with diabetes.Objective: Characterization of a pediatric population with T1D moved to adult health care between January/2001–April/2015.Methods: Cross-sectional study with retrospective analysis of medical records.R...

Introduction: Pituitary macroincidentalomas are rare, being found in only 0.2%–0.3% of the patients that undergo imaging studies for an unrelated reason. The majority of them are non-functioning adenomas.Case Report: Woman, 77 years-old, with type 2 diabetes mellitus, hypertension and primary hypothyroidism. She was referred to Endocrinology due to a pituitary incidentaloma (18 mm of maximal diameter, with extension to the cavernous sinus and to the...

Primary hyperparathyroidism (PHPT) is frequently diagnosed as an incidental finding of hypercalcemia. Overt bone disease (osteitis fibrosa cystica or brown tumor), with history of pathologic fractures is a rare presentation.A 48-year-old woman was admitted in with pain in the right thigh after a trivial fall. She also complained of generalized weakness and lethargy over the last 2 years. Her medical history mention multiple bone fractures in the last 6 y...

Introduction: Bariatric surgery improves lipid profile. A still unanswered question is whether this improvement is merely weight dependent or also results from factors inherent to specificities of the bariatric procedure itself. We aimed to study lipid profile 1 year after bariatric surgery and compare its changes between the different procedures in patients matched for initial weight and for weight loss.Methods: We retrospectively analysed patients subm...

Introduction: Most obese subjects have a normal thyroid function. Despite that, serum TSH seems to be slightly higher in this population, with a positive correlation with the degree of obesity.Objective: Evaluation of the relationship of serum TSH with BMI, weight, and HOMA-IR in euthyroid obese subjectsMethods: Three hundred obese subjects attending an Obesity Outpatient Clinic and submitted to bariatric surgery between January 20...