Endocrine Abstracts

Aims: Despite the plethora of testosterone therapies, Successful testosterone replacement remains a challenge. We assessed patient empowerment, treatment satisfaction and adherence to current testosterone replacement guidelines.Methods: Data were collected from case notes and a testosterone diary questionnaire in 16-patients with testosterone deficiency.Results: Median age was 46-years (range 21–69). All patients received an e...

Introduction: Myxoedmea coma is an extreme expression of hypothyroidism with a high mortality rate. It is rarely associated with thyroid lymphoma.Case report: A 66-year-old lady presented acutely unwell with a two week history of cough and shortness of breath. She was hypothermic, hypoxic with clinical and radiological signs of pneumonia. Her TSH was 99.8 mU/L and T4 less than 5 pmol/L with strongly positive thyroid microsomal antibodies, raised WBC and ...

Introduction Adrenal myelolipomas are rare small benign tumours composed of mature fat and hemopoietic tissues, which can be associated with congenital adrenal hyperplasia (CAH). We report a rare case of massive bilateral adrenal myelolipomas.Case report A 48 year old gentleman with CAH diagnosed during childhood presented at a routine endocrine appointment. He had not regularly attended his appointments or taken his steroids f...

Introduction Adrenal myelolipomas are rare small benign tumours composed of mature fat and hemopoietic tissues, which can be associated with congenital adrenal hyperplasia (CAH). We report a rare case of massive bilateral adrenal myelolipomas.Case report A 48 year old gentleman with CAH diagnosed during childhood presented at a routine endocrine appointment. He had not regularly attended his appointments or taken his steroids f...

Purpose: The aim of this study was to evaluate the effects of methomyl 25%WP (Lannate, carbamate broad spectrum insecticide) on the reproductive parameters in female Wistar rats during pregnancy and the possible protective role of vitamin E against methomyl-induced toxicity.Methods: The animals were randomly divided into four groups, eight of each. Group I served as control; Group II received orally a dose of methomyl (Met, 10 mg/kg per day), Group III w...

Background: In people with HIV on ARV treatment receiving Dolutegravir (DTG)-based regimen, weight and lipodystrophy have been reported.Aim: The aim of this is to evaluate the effect of DTG on the lipid profile and fat distribution on patients who have been switched from a non to a Dolutegravir (DTG)-based regimen on the lipid profile and fat distribution.Methods: One hundred patients above 18yrs of age were recruited into two arms...

Frequent measurement of blood glucose among hospitalized patients including those in critically ill areas is routinely practiced. Evidence suggests that tight glycaemic control among hospitalized patients reduced complications such as sepsis and has been shown to reduce length of stay. Most commercially available devices have not been assessed in critically ill patients, furthermore point of care (POC) glucose testing among paediatric populati...

Frequent measurement of blood glucose among hospitalized patients including those in critically ill areas is routinely practiced. Evidence suggests that tight glycaemic control among hospitalized patients reduced complications such as sepsis and has been shown to reduce length of stay. Most commercially available devices have not been assessed in critically ill patients, furthermore point of care (POC) glucose testing among paediatric populati...

Background: Adrenal insufficiency has been well established in patients with pulmonary tuberculosis in Nigeria. It has however not been well documented in patients with extra pulmonary TB. This study compared the adrenal function in patients with pulmonary TB vs those with extra pulmonary TB.Methods: We randomized 100 cases of pulmonary TB and 50 cases of diagnosed extra pulmonary TB, with the aim of assessing the adreno-cortical functions using both ser...

Introduction: Hypercalcaemia is a relatively common medical condition affecting around 1% of the general population. Around 90% of the cases are due to either primary hyperparathyroidism (PHPT) or malignancy. Familial hypocalciuric hypercalcaemia (fHH) is a rare autosomal dominant condition that can result in hypercalcaemia. It has an estimated prevalence of1 in 78 000. In most of the cases, fHH is due to a mutation in the calcium-sensing receptor gene (CaSR). Other rare cases...