Endocrine Abstracts

Introduction: Incretin based therapeutics have commonly been used in the last years for the management of patients with type 2 diabetes mellitus (DM). Linagliptin is a member of “dipeptidyl peptidase 4” (DPP-4) inhibitors and often preferred owing to some advantages over the others. We present a diabetic case developing skin findings after the initiation of linagliptin.Case: 66 year-old woman with a history of type 2 DM for 10 years was admitte...

Background: Fractalkine (CX3CL1) is known to convey its signals through a single G-protein coupled receptor (CX3CR1). It is characterized as a structurally unique chemokine with both membrane-bound and soluble forms. Fractalkine expression has been detected in activated or stressed endothelial, smooth muscle, skeletal muscle, macrophages, neurons, hepatocytes and adipocytes. Inflammation up regulates Fractalkine particularly in adipose tissue of obese individuals.<p class=...

Introduction: Most of the human studies suggested an association between obesity and low 25(OH)D3 0levels. It has been proposed that co-existence of vitamin D deficiency may have a role in the development of IR in obesity. We aimed to reveal whether any association was present between IR and 25(OH)D3.Materials-methods: 223 obese patients referred to our clinics were evaluated for the study. 24 patients with known diabetes mellitus were excluded. Finally,...

Introduction: Non-alcoholic fatty liver disease (NAFLD) is a common cause of impaired liver functions. It is associated with hepatic and adipose tissue insulin resistance (IR) as well as decreased whole-body insulin sensitivity. Thyroid hormones are important for the intrahepatic metabolism of lipids. Thyroid disorders have been associated with IR due to various mechanisms such as altered insulin secretion and lipid levels.Aim: The aim of our study was t...

A 26 year old lady under investigation for infertility was referred to our endocrine clinic for raised testosterone levels at 6.6 nmol/l (0.5–2.8).she had regular period with no features of hirsutism. Her past medical history included common acute lymphoblastic leukaemia on chemotherapy, liver cirrhosis with portal hypertension secondary to chemotherapy, Trans jugular intrahepatic portosystemic shunt (TIPS) insertion for bleeding gastric varices.Cli...

There is a rising use of Aluminium oxide nanoparticles (Al2O3NPs) in many branches of industry and personal care products. Because of these uses, their impact on the environment must be considered and investigated. Almost nothing is known about the effects of Al2O3NPs on semen quality and reproductive hormones. Possible mechanisms for the cytotoxicity of Al2O3NPs are still being discussed, but oxidative stress m...

Introduction: Few studies have investigated the effect of gastric bypass surgery on lipid profile in obese patients with type 2 diabetes mellitus. We aimed to evaluate changes in lipid profile in obese diabetic patients undergoing Roux-en-Y gastric bypass (RYGB) surgery.Method: We retrospectively analysed 71 obese type 2 diabetic patients (46 women, 25 men) who underwent RYGB surgery. Weight, body mass index (BMI), total cholesterol (TC), high-density-li...

Aim: To investigate the herbal medicines (HM) used for thyroid disease, their effects and use rates in Turkey.Materials and methods: A total of 547 patients (494 females and 53 males) had a thyroid disease were included in the study. The patients were questioned whether they used any alternative therapies or HM for their thyroid disease. The patients who used HM were asked about the kind of the HM, and duration of use. The data regarding the dose of the ...

Introduction: The role of Vitamin D in bone formation and cardiovascular health could not be overemphasized. Sunlight is one of the principal sources of this vitamin/hormone. However, it’s deficiency has been observed in sunlight affluent areas. The objective of the study was to determine the prevalence and risk factors of low vitamin D among adults in the tropics (Kano).Methods: The study was a community-based cross-sectional descriptive study. The...

Introduction: Sclerochoroidal calcification is an uncommon condition that classically manifests as multiple discrete yellow placoid lesions, often discovered as an incidental finding. It is ordinarily believed to be idiopathic, but is also associated with primary hyperparathyroidism. It is important that these patients are identified because of the systemic implications and treatable nature of these disorders.Case: 82 years old patient with history of Pr...