Endocrine Abstracts

Introduction: Increasing evidence suggesting an integral role of vitamin D in skeletal muscle function. The relationship between muscle strength and vitamin D status has been investigated to some degree in older populations, however there has been very little research in younger adult women. This study aims to measure the effects of vitamin D on handgrip strength in young adult women.Method: A total of 141 healthy women with mean age of 33.8±6.8 wer...

BACKGROUND: Adult Growth Hormone Deficiency (AGHD) is associated with reduced bone mineral density (BMD). PTH plays an important role in bone metabolism and reports have suggested target cell insensitivity to PTH as a contributor to the changes in bone turnover seen in AGHD. Although growth hormone replacement (GHR) increases BMD, the underlying mechanisms remain unclear.OBJECTIVES: To determine the effect of GHR on 24-hour PTH profiles, phosphocalcium ...

Introduction: Recent studies showed that post-menopausal osteoporosis and weight gain starts at the perimenopause stage, a period characterized by relatively stable estrogen and rising FSH levels. FSH is found to be associated with adiposity in women, which is also a great risk factor for type 2 DM. There is also a sharp increase in visceral adiposity during this life stage, which coincides with the emergence of disrupted energy balance and reduced physical activity. There is ...

Introduction: Patients with hypogonadism are at increased risk for cardiovascular diseases. Mean platelet volume (MPV), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) are hematological indices that are surrogate markers of adverse cardiovascular outcomes. This study investigated the platelet count, MPV levels, PLR, and NLR in patients with congenital hypogonadotrophic hypogonadism (CHH) and also studied the effect of testosterone replacement thera...

We report a Pakistani family of three adults and five children affected with same disorder. An 8-year-old boy referred to us for the management of osteogenesis imperfecta according to mother he was not gaining height, increasing head size, and bowing of legs since the age of 2 years. He had dental caries and brittle teeth. Two of his maternal uncles and one maternal aunt were suffering from the same disease; their children also showed similar complaints. A paternal uncle and a...

Objective: To analyze the remission factors of surgical treatment of acromegaly Methods: A retrospective study involving 227 patients with acromegaly: 143 (63%) women and 84 (37%) men were operated via trassphenoidal endoscopic approach for pituitary adenoma removal between the periods of 2018-2021. The average age was 45 years [36.00, 56.00]. 118 patients had 6 months follow-up period (3-40 months). The IGF-1 index used for the evaluation, which was cal...

Introduction: The prevalence of cardiometabolic disorders such as type 2 diabetes mellitus, dysipidemia and metabolic syndrome is increased in patients with Klinefelter syndrome (KS). The mechanism by which cardiometabolic risk increases in patients with KS remains to be completely elucidated. We investigated the presence of inflammation, insulin resistance and endothelial dysfunction in an unconfounded population of KS.Methods: A total of 31 patients wi...

Introduction: Adropin, a newly discovered peptide hormone, seems to have broad implications in energy homeostasis and metabolism in humans. Its main role is in maintaining appropriate carbohydrate and lipid economy. However, the aim of this study was to look at the novel role of adropin as a potential marker for cardiac function and nutrition status in hemodialyzed (HD) patients. To the best of our knowledge, this was the first study to consider the relationship between serum ...

Surveys for the assessment of the iodine status, carried out between 1997 and 1999 in Turkey showed that the country was severe to moderately iodine deficient. (National median UIC 36 μg/l, goiter prevalence % 31.8). Therefore, a national IDD control program had been implemented and mandatory salt iodization were applied by July 1999 with 50–70 mg/kg KI or 25–40 mg/kg KIO3 to the household salt.Objectives: To evaluate the curren...

Objectives: Assessment and monitoring which are two major components of a sustainable programme to eliminate IDD is being performed in Turkey since 1997. The initial survey, for the assessment of the iodine status, carried out between 1997 and 1999, showed that the country was severe to moderately iodine deficient (national median UIC: 36 μg/l, goiter prevalence % 31.8). Therefore, a national IDD control program had been implemented and mandatory salt iodization were appl...