Endocrine Abstracts

Background: Most studies of the metabolic syndrome (MS) among HIV patients focus on those receiving HAART. This study determined the prevalence and factors associated with MS among HAART naïve HIV patients in Kano, Nigeria.Methods: In this descriptive study, we evaluated 150 consecutive HAART naive HIV patients attending the HIV clinic of Aminu Kano Teaching Hospital. Data on socio-demography, relevant clinical history, anthropometric indices, and b...

There is growing evidence that bisphenol A (BPA) may adversely affect humans. BPA is an endocrine disruptor that has been shown to be harmful in laboratory animal studies. A comprehensive literature search found 91 studies linking BPA to human health; 53 published within the last year. This body of literature is showing associations between BPA exposure and adverse perinatal, childhood, and adult health outcomes, including reproductive and developmental effects, metabolic dise...

Introduction: Thiamine responsive megaloblastic anemia syndrome(TRMA), is an autosomal recessive disorder due to mutation of gene (SLC19A2) encoding thiamine transporter protein TRMA ischaracterized by a triad of anemia, diabetes mellitus, and sensorineural deafness.Case report: A 15 year old girl admitted to the ERwith diabetic ketoacidosis. She was diagnosed as neonatal diabetesat the age of 16 months and wasput on insulin therapy. Her parents arehealt...

Introduction: Androgen insensitivity syndrome (AIS), also known as testicular feminization, encompasses a wide range of phenotypes that are caused by numerous different mutations in the androgen receptor gene. where there is resistance to androgen actions influencing both the morphogenesis and differentiation of androgen responsive body structures AIS is an X-linked recessive disorder. This disorder includes a spectrum of changes ranging from male infertility to completely nor...

Introduction: Thyroid disorders such as subacute thyroiditis occur rarely in pregnancy. We report a recurrent case of subacute thyroiditis improved with the onset of pregnancy.Case report: A 32-year-old Turkish women who request pregnancy and planned insemination was referred due to malaise and neck pain in the left side a week ago. She was presented with low-grade fever, fatigue, pharingitis symptoms, neck pain and extremely tenderness in the right side...

Objective: To study the growth response to GH treatment in GH deficient patients. Also to report the possible side effects emerging during treatment with GH.Patients and methods: 477 GH deficient (GHD) children were included in the study. All patients received biosynthetic GH therapy at a dose of 20 IU/m2 per week. Patients were followed up for a minimum of 1 year and up to 6 years as anthropometric assessment was performed every 3 months, whi...

Objective: The aim of this study was to determine the change in serum ischemia-modified albumin (IMA) level and oxidative stress markers (total antioxidant status, TAS, total oxidant status, TOS) in patients with metabolic syndrome (metS).Research design and methods: We studied 52 metS patients (56.74±12.75 mean age), and 36 control subjects (54.47±6.52 mean age). The presence of metS was diagnosed according to National Cholesterol Education Pr...

Introduction: Obesity and its related diseases like high blood pressure are the main reason of coronary heart diseases that are the second main cause of mortality in I.R of IRAN. The significant rise of obesity in the last decade resulted in corresponding increase in the prevalence of hypertension.Objective: To detect obesity and hypertension, and the relationship between them among Semnanian people, Iran, 2007Methods: In this cros...

Background: Autoimmune thyroid disease is a common cause of thyroid dysfunction, either Graves’ disease causing hyperthyroidism or Hashimoto’s thyroiditis causing hypothyroidism. It has been noted that patients suffering from autoimmune hypothyroidism can transform to hyperthyroidism and vice versa. We report the case of a patient with long standing autoimmune hypothyroidism presenting with active thyroid eye disease and subsequently diagnosed with Graves’ disea...

Clinical case: A 30-year-old Eritrean presented as an emergency to the orthopaedics surgeons with radicular back pain. Following L3/L4 spinal decompression, he was noted to be classically acromegaloid and was transferred to the Endocrine Unit, where a mild bitemporal upper quadrantinopia was noted. GH was massively elevated at 1200 mU/L, IGF1>130 nmol/L, with associated corticotroph and gonadotroph insufficiencies requiring replacement. MRI showed a large pituitary adenoma...