Endocrine Abstracts

Introduction: Long term control of glucotoxicity has been shown to increase the secretion of insulin and C-peptide (Cp) from beta cells. However, there is limited data concerning the effect of short term glycemic control and reversal of glucotoxicity on basal Cp. We aimed to investigate the change in serum Cp levels after short term glycemic control in patients with uncontrolled type 2 diabetes mellitus (DM).Materials and methods: A total of 123 patients...

Background: Hypothyroidism is one of the most common forms of thyroid dysfunction. And it causes disturbance in electrolyte balance. The increase or decrease in plasma sodium and potassium levels were found to be associated with increase mortality.Objectives: The aimed of the study to measure plasma sodium and potassium levels in Sudanese patients with hypothyroidism.Method: The study is retrospective case control study included 50...

Background: The use of Dolutegravir (DTG) in the treatment of patients with HIV has been associated with reports of unexpected excess weight gain. The present study aimed to investigate the effect of DTG on the adrenal cortisol levels of HIV patients initiated on antiretroviral therapy (ART).Methods: Adult patients (≥18 years) newly initiated on ART were recruited into two groups (n-100 participants in each group). One group was initiated on a DTG-...

Background: The use of Dolutegravir (DTG) in the treatment of patients with HIV has been associated with reports of unexpected excess weight gain. The present study aimed to investigate the effect of DTG on the adrenal cortisol levels of HIV patients initiated on antiretroviral therapy (ART).Methods: Adult patients (≥18 years) newly initiated on ART were recruited into two groups (n-100 participants in each group). One group was initiated on a DTG-...

A 74-year-old male presented to hospital following an episode of brief loss of consciousness and several hours of post ictal confusion. There was no witnessed seizure activity, tongue biting, or incontinence. His past medical history included SCC right scalp, TIA and primary hypothyroidism. He had been commenced on Cemiplimab (immunotherapy) for metastatic SCC seven months before. On assessment, he appeared well and general examination including neurological examination was no...

Grave’s disease is an auto-immune disorder which responds well to medication and up to half of the patients who take anti-thyroid drugs go into remission. We present a patient with Graves’ disease, who developed acute hepatitis associated with Carbimazole and, re-challenged with Carbimazole when she represented with in fast atrial fibrillation (AF) with relapse of hepatitis. A 75 year-old lady admitted with palpitation and chest tightness. She had a background of par...

Background: The exposure to HAART has increased the chances of developing Diabetes among HIV patients. Hyperglycaemia is more common among those on Protease inhibitors (PI)-based regimens compared to other regimens. Glycated hemoglobin (HbA1c ) is now being recommended by the American Diabetes Association (ADA) for the screening of Diabetes because of convenience as it does not require fasting.Objective: We aimed to dete...

Background: The exposure to HAART has increased the chances of developing Diabetes among HIV patients. Hyperglycaemia is more common among those on Protease inhibitors (PI)-based regimens compared to other regimens. Glycated hemoglobin (HbA1c ) is now being recommended by the American Diabetes Association (ADA) for the screening of Diabetes because of convenience as it does not require fasting.Objective: We aimed to dete...

Introduction: Adrenal venous sampling (AVS) is widely used when investigating primary hyperaldosteronism. In this study we reviewed adrenal aldosterone and cortisol values for measurement range and for biochemical concordance with intervention in patients being investigated for aldosterone producing adenoma (APA).Methods: Retrospective review of AVS procedures performed at our institution during three years (May 2016–May 2019) was conducted. Aldoste...

The most frequent pathology of primary hyperparathyroidism presented with the findings of hypercalcemia is parathyroid adenoma. Some patients having the signs of primary hyperparathyroidism may have intrathyroidal parathyroid adenoma and it may be overlooked. We present a case of intrathyroidal parathyroid adenoma presented with bone pain.47-year-old female patient referred to our clinics with bone pain and she had no pruritus, dry mouth, dyspepsia, abdo...