Endocrine Abstracts

Growing interest in the role of vitamin D in many disease conditions as well as wide availability of vitamin D assays has led to a marked increase in its measurement. Although there are multiple circulating metabolites of vitamin D, those of interest are 25-hydroxyvitamin D2 and D3 and measurements of their relative concentrations is considered helpful. We reviewed vitamin D levels (D2 and D3) obtained on our patient population visiting a large teaching hospital.<p class="...

Forty-seven years old lady presented to another hospital with symptoms of diarrhea and sleep disturbance. She was found to have abnormal thyroid function tests (TFTs) with fT4 44 fT3 12 and TSH 3.4. She had no goiter or thyroid eye signs. Thyroid ultrasound showed a multinodular goiter and an uptake scan was consistent with thyrotoxicosis.She was commenced on carbimazole and in 2001 radio-iodine was administered for a presumed diagn...

Introduction: In this study, we aimed to examine the weight alterations after the medical treatment and compare the effects of medical treatment in obese patients who applied to Endocrinology Policlinic.Material and method: We examined the patients who were diagnosed as obesity and initiated medical treatment at Endocrinology and Metabolism Diseases Policlinic in Inonu University Medical Faculty between Agust 2005–May 2008. Patients were divided int...

Introduction: It is known that certain endocrine disorders are related to each other and occur together due to their autoimmune aetiology. Patients with an autoimmune disease must be considered at risk for other autoimmune disease. Addison’s disease usually presents with recurrent hypoglycaemia in subjects with type 1 diabetes mellitus.We present a case Addison’s disease in type 1 diabetes presenting with severe hyperglycaemia.<p class="abs...

Introduction: Cushing’s syndrome is characterised by glucocorticoid excess. This is more commonly caused by excess adrenocorticotropic hormone (ACTH) produced either by a pituitary tumour (Cushing’s disease) or ectopic secretion. An example of the latter is the production of ACTH by a lung carcinoma (typically small cell)1. Other causes of Cushing’s syndrome include long term steroids or adrenal carcinoma.Case history: A 62-year...

Introduction: Central Serous Retinopathy (CSR) is a condition characterized by the accumulation of sub-retinal fluid at the posterior pole of the fundus, creating a circumscribed area of serous retinal detachment. It is associated with increased levels of endogenous or exogenous glucocorticoids and has been described in patients with Cushing’s syndrome (CS).Here we report on two cases we recently managed in our unit, with central serous retinopathy ...

Introduction: The biochemical diagnosis of hypophosphataemic rickets relies on measurement of tubular phosphate reabsorption. However, as the renal tubules are immature at birth and the reference range for urine phosphate excretion is not well defined in young children, there is uncertainty about how early in life a biochemical diagnosis of phosphate wasting can be made. In addition, the benefit of early treatment of hypophosphataemic rickets is unclear.<p class="ab...

Clinical case: A 37 year-old Caucasian man was admitted with sudden onset lower limb weakness following a carbohydrate-heavy meal the night before. Pulse was 110/min, sinus rhythm, BP 167/92 mmHg. There was generalised muscle weakness, particularly in his legs, with hyporeflexia and hypotonia. There was no sensory deficit and plantar responses were downgoing. Serum K+ was 2.4 mmol/L, associated with typical ECG anomalies, and was corrected with 40 mmol intravenous KCl followed...

Fine needle aspiration biopsy (FNAB) is the investigation of choice for patients with thyroid nodules in secondary care. Ideally the following standards should be met: assessment within 2 weeks of referral; FNAB performed in the first visit; consent obtained and documented; communication of the result in person.A cohort of 64consecutive patients (57 female) was identified. The median age was 49 (16-78). Thyroid function tests were normal in 89% of patien...

Fine needle aspiration biopsy (FNAB) is the investigation of choice for patients with thyroid nodules in secondary care. Ideally the following standards should be met: assessment within 2 weeks of referral; FNAB performed in the first visit; consent obtained and documented; communication of the result in person.A cohort of 64consecutive patients (57 female) was identified. The median age was 49 (16-78). Thyroid function tests were normal in 89% of patien...