Endocrine Abstracts

Introduction: A rare cause of adrenal incidentaloma is congenital adrenal hyperplasia (CAH). Nonclassic CAH is one of the most frequent autosomal recessive disorders. Most cases of nonclassic CAH are never diagnosed due to very mild symptoms.Case report: A 62-year-old woman admitted at our Department for right adrenal incidentaloma sized 39×34×38 mm confirmed by MRI. She was asymptomatic. Her past medical history included stabile hypertension, ...

Objective: Primary hyperparathyroidism (PHPT) is systemic disease affecting bone metabolism and glucose homeostasis. Patients with PHPT are insulin resistant and have atherogenic dyslipidaemia. Osteocalcin (OC) is bone biomarker associated with increased insulin secretion and insulin sensitivity and decreased visceral fat The aim of our study was to evaluate the body composition and levels of bone biomarkers (osteocalcin and betaCTx), insulin sensitivity and lipids in patients...

Introduction: Calcium plays a key role in myocardial contractions and relaxation. Heart failure induced by hypocalcemia is rare but potentially reversible case.Case report: We present the case of 50 years old woman with muscle cramps, cataract, chest pain and dyspnea that lasts 2 years. In regional health center she was treated as psychiatric patient and COPD. Last few months she became extremely malaise with crural edemas and walking distance of 100 m. ...

It was reported that patients with primary hyperparathyroidism (PHPT) are insulin resistant, and that surgical treatment may improve insulin sensitivity in this group of patients. The aim of our study was to evaluate the effect of surgical treatment on insulin sensitivity and acute insulin response (AIR) in patients with PHPT.Methods: In patients with PHPT (n=37; age: 57.72±8.29 years, BMI 26.22±4.37 kg/m2) euglycemic–hyp...

It was previously shown that patients with primary hyperparathyroidism (PHPT) are insulin resistant.Aim: The aim of our study was to evaluate the effect of surgical treatment on glucose tolerance, insulin secretion and sensitivity (SI) in patients with PHPT.Material and methods: In 26 patients with PHPT (age: 57.15±9.54 years, BMI 26.00±4.55 kg/m2, PTH 276.61±64.83 ng/l, Calcium 2.95±0.19 mmol/l)) AIR...

Objective: It was previously shown that primary hyperparathyroidism (PHPT) might induce impaired renal function and chronic renal failure. The aim of our study was to evaluate the effect of surgical treatment on parameters of calcium and phosphate renal metabolism and renal function in patients with PHPT.Material and methods: In 26 patients with PHPT (age: 57.15±9.54 years, BMI 26.00±4.55 kg/m2, PTH 276.61±64.83 ng/l, Calcium 2....

Objective: It was previously shown that patients with primary hyperparathyroidism (PHPT) have atherogenic dyslipidaemia. The aim of our study was to evaluate the effect of surgical treatment on lipid levels in patients with PHPT.Material and methods: In 26 patients with PHPT (age: 57.15±9.54 years, BMI 26.00±4.55 kg/m2, PTH 276.61±64.83 ng/l, Calcium 2.95±0.19 mmol/l) Total cholesterol (TC), HDL-C, LDL-C, triglyceride (TG),...

Introduction and aims: Recent epidemiological studies have suggested serum gamma glutamyltransferase (GGT) within its normal range might be an early marker of oxidative stress. Oxidative stress appears to be a key component of many reactions associated with chronic inflammation. Obesity is associated with elevated levels of biomarkers of inflammation and endothelial dysfunction. Oxidative stress and inflammation are also known to play critical roles in the pathogenesis of vasc...

Polycystic ovary syndrome (PCOS) is associated with adiposity and metabolic changes predisposing to insulin resistance. Because the recently discovered GH secretagogue, ghrelin is intimately involved in the control of appetite and weight regulation, we investigate ghrelin levels in non-obese and obese PCOS patients. Ten obese (BMI=32.50±1.57 kg/m2) and ten non-obese (BMI=20.45±0.51 kg/m2) patients with PCOS and their respective controls were eva...

It was previously shown that patients with primary hyperparathyroidism (PHPT) are insulin resistant. The aim of our study was to evaluate the effect of surgical treatment on insulin sensitivity and lipid levels in patients with PHPT. In 21 patients with PHPT (age: 56.24±8.69 years, BMI 25.2±3.81 kg/m2) lipid levels (TC, HDL, LDL, TG, Lp(a)) and insulin sensitivity were determinated before and 4 months after surgical treatment. Insulin sensitivity was evalu...