Endocrine Abstracts

Anonymised therapeutic data has been available for all patients in NI across 364 general practices since 2008. The database records age, gender, trusts and postcodes, which allows for spatial deprivation analyses. Patients were categorised in deciles (1-most deprived, 10-least) according to published criteria. We examined carbimazole (CBZ) and propylthiouracil (PTU) prescriptions over 10 years (2010 to 2019). Patients treated definitively with surgery/radioiodine are invariabl...

CHI is a disorder of dysregulated insulin release characterised by severe recurrent hypoglycaemia. Mutations in genes encoding the beta-cell sulphonylurea receptor (ABCC8) and inward-rectifying potassium-channel (KCNJ11) are the commonest genetic cause of CHI, followed by that encoding glutamate dehydrogenase (GLUD-1). Histologically, disease pathology is subdivided into diffuse or focal disease; the latter associated with paternal mutations and somatic lo...

Introduction: In 2020, Thyroid cancer was responsible for 586,000 cases worldwide, ranking in 9th place in terms of incidence. It is also the most common type of cancer of the endocrine system in 2020. According to the literature, thyroid cancer have reported an increase in the incidence worldwide. However, it varies greatly from country to country. The aim of this work was to evaluate the incidence of thyroid cancer and its trend in northern Tunisia between 1990 and 2019....

Introduction: The diagnosis of the metabolic syndrome is less definite in children and adolescents compared to adults. The International Diabetes Federation (IDF) and National Cholesterol Education Program Adult Treatment III guidelines (NCEP ATP III) have proposed two different criteria for its diagnosis in these age groups. In this study we planned to compare these two criterias in detecting the metabolic syndrome in obese and overweight adolescents in a study group in North...

Background and objectives: Recent data on median urinary iodine concentration (UIC) in schoolchildren showed that Italy has achieved iodine sufficiency. Nevertheless, no national data on iodine nutrition in pregnancy are available. Therefore, a multicentre study coordinated by the Italian National Observatory for Monitoring Iodine Prophylaxis (OSNAMI), was launched in 8 Italian regions representative of the Northern (Lombardy, Veneto, Liguria), Central (Tuscany, Lazio) and Sou...

We describe the development of a new adolescent gender identity dysphoria (GID) service in Northern Ireland (population 1.8 million). Historically patients with GID <18 years were referred to The London joint Tavistock UCH adolescent GID service on a case by case basis. Following the commissioning of a GID service in Northern Ireland, a team of clinical psychologists, paediatric endocrinology nurse specialists, psychiatrist and paediatric endocrinologists, the first GID cl...

Objectives: Some hypothyroid patients are critical of their care, although this appears to vary between countries. The quality of thyroid care delivered, and the perceived patient experience may be influenced by characteristics of specialists such as age, sex, experience, and workplace setting. Here, we aimed to explore geographical differences in thyroid specialist characteristics.Methods: THESIS is a large European questionnaire survey of thyroid speci...

Background: Levothyroxine (LT4) is considered the standard of care for hypothyroidism, however 5-10% of hypothyroid individuals complain of persistent symptoms despite achieving biochemical euthyroidism on LT4.Methods: 17,247 thyroid specialists from 28 countries were invited to participate in a survey. It enquired about respondents’ perceptions of the cause of hypothyroid-like persistent symptoms and how the prevalence of such complaints had change...

In this lecture, fundamental concepts in the area of molecular biology will be presented. These include biology’s and biotechnology’s central dogma; the ‘human genome project’; the discordance between human gene number and corresponding protein number; and gene cloning techniques. Also presented will be procedures used to determine gene number and location (Southern blotting) and levels of gene expression at the RNA (Northern blotting, reverse transcription...

Background: The incidence of thyroid cancer in South Korea has increased rapidly. Increase in medical surveillance and access to health care services have enhanced the detection of asymptomatic tumors. We investigated the differences of tumor characteristics between South Korean patients and Northern Italian patients subject to different healthcare systems.Methods: The demographic, histopathologic and management features of thyroid cancer operated in two...