Endocrine Abstracts

Background: The age at adiposity rebound (AR), at which BMI begins to rise after infancy around the age of 5 years, is associated with obesity and metabolic alteration in later life. Given that polycystic ovary syndrome (PCOS) has strong metabolic components, early growth patterns could reveal predisposition for PCOS. Thus, we aimed to investigate the associations of growth trajectories from birth to puberty with PCOS diagnosis,vbody composition and hyperandrogenism later in a...

Liver fatty acid-binding protein (LFABP) is a 14 kDa cytoplasmatic protein found in hepatocytes and enterocytes of the small intestine. It binds long chain fatty acids (LCFA) and other hydrophobic ligands and is thought to play an important role in intracellular LCFA transport.We investigated the regulation of LFABP gene expression by thyroid hormone (T3) and peroxisome proliferator-activated receptor alpha (PPARalpha) ligand clofibric acid.<p class=...

IntroductionThe problem of ecologically caused iodine deficiency is acute in many countries around the world, including Ukraine, where the endemic zone for the development of iodine deficiency is Northern Bukovina. The possible participation of iodine in the induction or manifestation of autoimmune processes in the thyroid gland and their role in reproduction is discussed. Iodine deficiency is significantly higher in infertile women than in women with no...

COVID-19 is affecting Northern Italy since early 2020 and long-term consequences of the pandemia are progressively coming to light. Over the past months, a marked increase in the number of adults with rapid-onset severe diabetes has been observed at the Diabetes Clinic thus prompting an evalutation into possible links with COVID-19. Of note, diabetes and hyperglycaemia are known to worsen during COVID-19 and there are several reports of new-onset hyperglycaemia during SARSCoV2...

Introduction: The current UK guidelines (NICE TA791) recommend the use of romosozumab, a monoclonal sclerostin inhibitor, for patients at high imminent risk of fragility fractures. However, elderly patients with a very high risk of fractures often exhibit frailty and other comorbidities. This retrospective survey was conducted in a major trauma centre in northern England to evaluate the potential utilisation of romosozumab in a real-world setting.<p class=...

Introduction: Polycystic ovary syndrome (PCOS) is the most prevalent endocrine and metabolic disorder of women of reproductive age. Comprehensive metabolic profiling of women with PCOS across different ethnicities will help in understanding the pathophysiology of this condition.Methods: The Born in Bradford (BiB) study is a UK longitudinal birth cohort. Profiling of circulating lipids, fatty acids, and metabolites was do...

Background: Women with polycystic ovary syndrome (PCOS) experience increased weight gain during life, thus weight management and preventing weight gain should be the first line treatment. Weight loss is usually self-initiated because practical support for weight management is often limited or even lacking. Perception of overweight is considered an important prerequisite for weight loss attempts, although there is no prior research regarding women with PCOS. The main aim of the...

Background: Obesity is strongly associated with a state of chronic low grade systemic inflammation and insulin resistance (IR). IR at the molecular level may be defined as a diminished activation of the metabolic phosphatidylinositol-3-kinase (PI3K)/Akt pathway of insulin. On the other hand, inflammatory response may be activated by NF-κB. Subject with obesity have elevated plasma levels of saturated fatty acids, such as palmitic acid (PA), which triggers insulin and infl...

Introduction: The prevalence of diabetes mellitus (DM) in patients with coronavirus disease (COVID)-19 varies widely, depending on population characteristics, country, age and disease severity. Moreover, pre-existing DM seems to double the risk of both critical COVID-19 and mortality.Aim: To evaluate incidence and mortality risk of COVID-19 in a large diabetic population in Northern Italy.Methods: A retrospective, observational, bi...

Introduction: Massive anti-SARS-CoV-2 vaccination campaigns have been established as the cornerstone of confronting the current COVID-19 pandemic. Subacute thyroiditis (SAT) comprises an inflammatory process in the thyroid gland, mostly due to viral infections of the upper respiratory tract, although it may rarely occur after vaccine administration. To date, a few cases of SAT related to anti-SARS-CoV-2 vaccines have been reported globally. Hereby, we present the case of a pat...