Endocrine Abstracts

I received a clinical fellowship from the Medical Research Council to study osteoporosis at the University of Edinburgh in 1978. I furthered my clinical research training by working at the Mayo Clinic under the supervision of Dr B L Riggs where I worked for five years. I developed a number of new approaches for studying osteoporosis while at the Mayo Clinic including the use of stable (non-radioactive) isotopes to measure the absorption of calcium from food, the use of an infu...

Objective: Diabetes mellitus is among the most common of chronic disorders with increasing prevalence worldwide, affecting 50 000 citizens in Montenegro. The insulin pump is a medical device that works on the principle of continuous insulin injection, and is used in the control of diabetes in insulin dependent patients. The objective of this study was to highlight the role of nurse in education of the patients, implantation of insulin pump and nursing networking for insulin pu...

Introduction: Amyloidosis due to Apo A-I Leu75Pro mutation is a rare form of hereditary amyloidosis with systemic involvement mainly of testicle, kidney and liver. This disease finds a wide prevalence in the province of Brescia (Northern Italy), which represents a geographic uniqueness for the spread of this amyloidosis form. Somefeatures of this disease have not yet been described.Purpose: To describe the frequency of organ damages in this amyloidosis f...

The calcium receptor (CASR) serves as one of the main regulators of the calcium homeostasis. CASR is expressed in among other tissues parathyroid chief cells and kidney tubule cells. It has been hypothesized that CASR gene variations are responsible for low circulating calcium levels together with hypercalciuria and thereby increased risk of kidney stones. The CASR gene polymorphism A986S has been shown associated to elevated serum calcium levels in vivo<...

Introduction: The possibility of progression of subclinical hyperthyroidism (SH) to overt hyperthyroidism (OH) is a critical point in deciding whether to treat this situation.The aim of this study is to evaluate the rate of progression of SH to OH and the factors influencing this outcome.Methods/design: This is a retrospective study at an endocrine referral service in Northern Greece. Data from patients with SH diagnosed between 19...

The aim of this epidemiologic study, performed in a wide population of high-school students in Northern Italy, was to obtain an unbiased estimate of the prevalence of hyperandrogenic states in adolescents and young females.2052 female students, aged 15–19 years, were consecutively contacted. 939/2052 (45.8%) refused to participate in the study, but 431 of the 939 non-participants (45.9%) agreed to fill out a brief questionnaire aimed to broadly asse...

Introduction: The aim was to compare the incidence of type 1 diabetes between immigrant Moroccan and Romanian children and background population in Piedmont, Italy, and between Moroccan children living in Italy and their counterpart in Morocco.Patients and methods: All new cases of type 1 diabetes aged 6–13 years in Piedmont and Morocco in 2005–2009 were retrieved by regional registries. Numbers of children regularly registered to primary and m...

Introduction: Pregnancy is a stress test on maternal thyroid and pregnant women may be more susceptible to thyroid dysfunction. Consequences of this may be harmful for the mother and fetus. Smoking has been associated with alterations in thyroid hormone concentrations, but little knowledge exists on this association in pregnant women.Subjects and methods: The study population is large, prospective population-based Northern Finland Birth Cohort 1986 (n...

Introduction: Foetus is dependent on maternal thyroid hormone production during the first trimester. Thus, maternal thyroid dysfunction and thyroid antibodies may affect thyroid function of the offspring.Subjects and methods: We studied a subcohort (n=2000 mother–child-pairs) from a prospective population-based Northern Finland Birth Cohort 1986 (singleton births, total n=9247) covering data throughout pregnancy, childhood and adolesce...

Introduction: Hyperandrogenaemia in adolescence is associated with hirsutism, acne and menstrual irregularity and is considered as an important risk for polycystic ovary syndrome and subsequent risk of cardiovascular disease and type 2 diabetes. The aim of this study was to establish if self-reported oligo/amenorrhea were associated with hyperandrogenemia and metabolic disturbances in adolescence.Subjects and methods: A cross sectional study using postal...