Endocrine Abstracts

The aim of this study was to compare metabolic profile in hypertensive obese and lean subjects. The study population consisted of 76 patients. We measured fasting glucose and insulin levels, triglycerides, total, LDL and HDL cholesterol. We also estimated the BMI, WHR, systolic (SBP) and diastolic blood pressure (DBP). We used WHO criteria for abdominal obesity (WHR>0.90 men, >0.85 women), and WHO criteria for diagnosing the metabolic syndrome (triglyceride>1.7 mmo...

Ghrelin stimulates growth hormone (GH), prolactin (PRL) and cortisol release in rodents and healthy humans.Aim: to determine the effects of ghrelin on neuroendocrine response in patients with AN in this cross-sectional hospital based study, approved by the Local Ethical Committee. Twenty-five young women were studied: AN with very low body weight (BMI 12.0±0.4 kg/m2), partially recovered AN (PRAN 17.2±1.3 kg/m2) and consti...

The short-term results of transsphenoidal surgery as initial treatment for acromegaly were analyzed according to consensus defining the criteria for cure of acromegaly.Thirty nine newly diagnosed patients with acromegaly (20 females and 19 males, mean age 46.9 plus/minus 1.4 years, range 29-66 yrs), underwent transsphenoidal pituitary adenomectomy by the same neursurgeon. Patients have been assessed postoperatively at 8 weeks (GH after 75 g oral glucose ...

Objective: People are at higher risk for malignancy as they get older or have a strong family history of cancer.Aim: To collect family history of cancer in a large cohort of patients with pituitary adenomas (PA) in Outpatient clinic from years 2005–2017.Results: Overall 46% of 1100 patients with PA had a family member affected with cancer. Breast cancer in family members was reported in 15.3% of patients with prolactinomas whi...

ObjectiveThere are few data on long-term follow-up of patients with nonfunctioning adrenal incidentalomas (NFAIs). We aimed to determine the natural history of NFAI at 10 year follow-up. We also evaluated the associations between baseline body mass index (BMI) and changes of NFAIs’ and patients’ characteristics at follow-up period.DesignLongitudinal observational study.Patient...

IntroductionDiabetes mellitus (DM) is considered as equivalent to cardiovascular disease (CVD), so the intensive control of all risk factors for CVD in patients with DM is recommended. Risk factors for CVD include: dyslipidemia, hypertension, smoking, family history of CVD and albuminuria. In addition to being a sensitive and reliable marker for evaluation of kidney function, research suggests that cystatin C may be a useful predictor for the detection a...

AimDiabetic cardiomyopathy (DC) is congestive heart failure developed in diabetic patients, without coronary, hypertensive, valvular nor myocardial alcoholic disease. Aim of this stady was to confirm if presence of diabetic autonomic neuropathy (DAN) is correlating with development of DC in patients with diabetes.MethodsWe have evaluated 90 examinees: 30 of them with diabetes type 1(T1D), 30 with diabetes typ...

AimDepression in diabetic patients is related to low quality of life, inadequate abiding by diabetes diet, physical activity and drug therapy.Aim of the stady is determine the presence of depression and its impact on the level of metabolic control of the disease; impact of structured education on the level of knowledge and HbA1c in patient with diabetes type 1 (T1D)MethodsThe study included 38 patients with T...

Septooptic dysplasia is a clinically heterogeneous disorder characterized by optic nerve hypoplasia, pituitary hormone abnormalities and midline brain defects.clinical diagnosis requires the presence of at least two of the features of the classical triad. Here is male presented on endocrinology consult for the first time at the age of thirthy five. On clinical examination height and weight were normal, face hypogonadal, sparced facial and body hair, testicle hypotrophy, normoc...

Single nucleotide polymorphisms in the glucocorticoid receptor (GR) gene influence tissue sensitivity of GR. Several studies have shown different effects of BclI GR polymorphism on body composition and metabolic parameters. The objective of this study was to explore the effect of BclI GR polymorphism on the body composition and glucose metabolism. Biochemical tests and hormonal evaluation were performed in 106 consecutive women with adrenal incidentalomas (AI...