Endocrine Abstracts

Dietary therapy, programmed physical activity and cognitive-behavioral therapy are basic measures in the treatment of obesity. Cognitive-behavioral therapy applies methods which change eating habits of obese persons, aiming to remove barriers relating dietary therapy and programmed physical activity. The goal is to try efficiency of applying cognitive-behavioral therapy in the program for the reduction of body mass of obese persons, versus the application of dietary therapy an...

Diabetes mellitus (diabetes) can now be called the disease of modern times due to its increasing incidence especially in the more developed parts of the world. It is characterized by the inability of the body to produce and/or properly use insulin. In our work we engaged in research of type 1 diabetes in NOD animal model. The focus of our study was relatively recently discovered SGLT time in the small intestine, which are actively inhibited by Ca2+ zeolite. SGLT1 tr...

Why should we be suspicious of simple explanations in complex problems? The past decades have seen critical advances in understanding the regulation of growth hormone (GH) secretion. I spent many fruitful yers studying the actions of synthetic GH secretagogue, the GH releasing peptide-6 (GHRP-6), on human GH secretion. GHRP-6 mimicked GH releasing hormone (GHRH) but did not bind to GHRH receptor. Powerful joint action (synergism) of GHS/ GHRH was blocked in patients with hypot...

Introduction: Ovarian hyperthecosis (OH) is a rare condition, reported only in case reports and small case series and is characterized by severe hyperandrogenism leading to virilisation and insulin resistance. The term hyperthecosis refers to the presence of luteinized thecal cells within a hyperplastic ovarian stroma and the pathophysiology of this remains poorly understood. Despite the fact that hyperandrogenism is a relatively common clinical problem, severe hyperandrogenis...

Introduction: Addison’s disease is a rare disorder, described mainly in isolated cases. The two most common cause of primary adrenal insufficiency are autoimmune adrenalitis and adrenal tuberculosis, which is still the primary cause of primary adrenal insufficiency (PAI) in developing countries. Adrenal tuberculosis is difficult to diagnose, the classic presentation with non specific symptoms delay the diagnosis. In some cases, the background of tuberculosis and hyperpigm...

Background/Aim: Impact of age on hypothalamic –pituitary –thyroid axis, interesting from theoretical and practical aspects, have been studied. Our aim was to find out: correlation between T3 (triiodothyronine) and T4 (thyroxine) hormone level and old age, so as of other, for thyroid function relevant parameters: TSH (thyroid stimulate hormone), TRH (thyreothropin releasing hormone) test, thyroid ultrasonography, thyroid gland scintigraphy with 131 J, ...

Introduction: Chronic kidney disease (CKD) is growing problem nowadays. Disorder of mineral metabolism occurs in initialCKD and includes the changes of bone metabolism. Fibroblast growth factor 23 (FGF23) plays an important role in phosphate metabolism. Bearing in mind this physiological role of FGF23, but also it’s role in pathophysiology of mineral and bone metabolism, there is a growing interest in conducting clinical studies in patients affected by CKD. Our aim was to...

Introduction: Osteoporosis is a metabolic disease that is characterised by low mineral bone density (BMD) and increased risk of fractures. Weight loss reduced BMD and increased risk of hip fractures, while it reduces in a weight gain. Osteoporosis fracture risk and BMI correlate more frequently denied in recent studies. The aim of this study was to examine relationship between BMI and BMD in a group of postmenopausal women.Design: The study involved 100 ...

Adrenocortical carcinoma (ACC) is a rare (incidence 1–2 per 1 million population) and heterogeneous malignancy with incompletely understood pathogenesis, unknown etiology and poor prognosis. ACC tends to grow and metastasize rapidly if untreated. The majority of cases are incidental diagnoses of advanced stage disease that metastasizes precociously due to its tendency to invade vascular structures. Among adults presenting with hormonal syndromes due to tumor excess secret...

Purpose: The goal of the study was to determine: existence and degree of diabetic cardiovascular autonomic neuropathy (DCAN) depending on the type of diabetes; influence on systolic and diastolic function of myocardium and correlation with coronary disease and cardiovascular risk factors; possibility of early detection and diagnostic value of cardiovascular tests (CVT).Methods: The study involved 90 participants: 30 patients with type 1 diabetes (T1DM), ...