Endocrine Abstracts

Introduction: Increased levels of high-sensitivity C-reactive protein (hs-CRP) and interleukin 6 (IL-6) accelerates atherosclerosis and occurrence of cardiovascular complications in patients with type 2 diabetes (T2D). Intima-media thickness (IMT) is a surrogate marker of atherosclerosis in patients with T2D.Aim: The aim of the study was to evaluate the significance of determining inflammatory markers IL-6, hs-CRP and IMT, as atherosclerosis markers, dur...

Introduction: Merkel cell carcinoma is a rare and aggressive neuroendocrine skin cancer. It is characterized by a high rate of local recurrence after surgical resection as well as the occurrence of distant metastases. It mostly occurs in the elderly and the exact etiology is unknown. The most significant risk factors for its occurrence are exposure to ultraviolet light and the oncogenic effect of the Merkel cell polyoma virus.Aim: Demographic and clinica...

Context: Hyponatremia due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a very common condition in hospitalized patients. It is crucial to establish the cause of SIADH especially in order to exclude or detect an underlying malignancy. As SIADH can be caused by paraneoplastically produced arginine vasopressin (AVP), we hypothesized that its stable surrogate marker copeptin may be used as a diagnostic tool.Methods: We analyzed ...

Background: The goal of this project was to identify non-osmotic stimuli of arginine vasopressin (AVP) release during exercise. Non-osmotic AVP release can lead to severe hyponatremia in otherwise healthy marathon runners.Interleukin-1 (IL-1) increases during exercise and was shown to induce AVP in animal models. We here therefore investigated whether copeptin (a surrogate marker for AVP) increases upon exercise in young and healthy males, and whether this increase is regulate...

Objective: To collect clinical and treatment outcome data in a large patient cohort, and specifically to report experience with temozolomide (TMZ).Design: Cohort study based on an electronic survey open for participation to ESE members Dec 2015-Nov 2016.Results: Reports on 167 patients, 40 pituitary carcinomas, and 127 aggressive pituitary tumours were obtained. Median age at diagnosis was 43 (range 4–79) years. 59% of tumours...

Background: Long-term safety data (1998 to mid-2016) are reported for adult patients with GHD treated with GH (Norditropin® (somatropin), Novo Nordisk) as prescribed by treating physicians in the real-life clinical setting and enrolled in NordiNet® International Outcome Study (IOS) (NCT00960128), a non-interventional, multicentre study.Objective and hypotheses: To describe and report safety data and incidence rates (IRs) (...

Hyponatremia can unmask hypopituitarism and secondary adrenal insufficiency due to potent non-osmotic stimulation of vasopressin release under stressful conditions. Patients and methods: In a retrospective study 25 patients (13f/12m, age 58.9±18.6 years) with hyponatremia (119.7±10.5 mmol/l) were identified among 260 in-patients treated for hypopituitarism in our department over a decade. Results: Hyponatremia was recorded in 9.6% of our patients. In 84% it was the k...

Introduction: Skeletal complications are among most persistent and invalidating systemic impacts of acromegaly. Assessment of bone health in acromegaly by dual-X-ray absorptiometry (DXA) alone might be insufficient or even misleading.Patients and methods: Patients with acromegaly (n=170) were classified as active (n=104), operatively cured (n=34) or medically controlled (n=32). We excluded patients with metabolic bone ...

Introduction: Hypogonadotropic hypogonadism(HH) is mandatory treated with testosterone (T). However, gonadotropin(hCG/FSH) administration might be the challenging optimal therapy.Case 1: Male, 23-y-old, hypophisectomy pp. adenoma hromophobum, one month later- FSH 1.5 U/L, LH 0.55 U/L. Primogonyl(hCG) test; testosteronemia: 0 day 0.069, 3 day 19.01 nmol/l. After 5 m in ejaculate no sperm. 5 m after introduction of hCG twice weekly 1,500 i.u. and FSH+LH 15...

Background: Inadequate glucocorticoid (GC) replacement may be associated with overexposure to GC, which can adversely influence metabolic and cardio-vascular state of hypopituitary growth hormone deficient adult patients (A-GHD). In this study we compared metabolic profile of ACTH insufficient and sufficient patients in A-GHD not treated with GH.Patients and methods: A cohort of 260 patients (age 48.6±12 years and BMI 28.7±6.6 kg/m2)...