Endocrine Abstracts

Introduction: Insulin resistance (IR) is a well recognised feature in women with polycystic ovary syndrome (PCOS). The aim of this study was to analyse IR indices obtained from oral glucose tolerance test (OGTT), in different PCOS phenotypes.Methods: We evaluated 240 PCOS women (PCOS: 24.86±5.97 kg/m2; 25.25±4.98 years) diagnosed using ESHRE/ASRM criteria and 70 BMI-matched healthy women (controls: 26.14±4.86 kg/m2; 3...

Introduction: Although phenotype D is well recognised in clinical studies about PCOS, there is still a debate if this phenotype should be evaluated as part of PCOS spectrum. The aim of this study was to evaluate usual anthropometric characteristics in PCOS phenotypes.Methodology: We evaluated 365 PCOS women (PCOS: 25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 BMI-matched healthy women (Controls: 25.4...

Obesity is closely associated with PCOS and worsens its metabolic and reproductive characteristics. The aim of this study was to evaluate body composition in different PCOS phenotypes. We evaluated 365 PCOS women (PCOS: 25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 BMI-matched healthy women (Controls: 25.41±5.16 kg/m2; 30.35±5.62 years). PCOS were analyzed through four phenotypes: a (anovulation (ANOV)...

Introduction: A link between diabetes and coronary heart disease is well-known. The aim of this study is to examine the influence of actual and retroactive diabetes regulation parameters (admission glycaemia and HbA1C value) on duration of hospital stay and clinical outcome of T2DM patients suffered from NSTEMI/STEMI.Material and methods: Cross sectional study involved 103 examinees with past history of T2DM actually hospitalised in CCU due to acute myoc...

Adrenocortical carcinoma (ACC) is rare malignancy associated with limited treatment options and poor prognosis. The aim of this study is to review clinical characteristics and survival of patients with ACC in single centre. We retrospectively analysed 60 patients (37 female and 23 males) with pathologically confirmed ACC who were treated at our institution between January 2005 and December 2014. Staging was performed according to European Network Study of Adrenal Tumours (ENS@...

Introduction: Medullary thyroid carcinoma (MTC) is a malignant neoplasm derived from the parafollicular cells of the thyroid gland. Approximately 25% of them are caused by germline mutations of the RET gene, presenting as a part of FMTC, MEN2A or MEN2B syndrome.Design of the study: We analysed 213 consecutive patients with MTC (142 females, 71 males, age 6–78, mean 45 years), treated in a single centre from 2004 to 2014. Direct DNA sequenci...

Introduction: Literature data suggests increased fracture risk in women with diabetes mellitus type 2 but the underlying mechanism is not fully understood.Aim of the study was to analyse bone turnover parameters in women with DM2 and in healthy women with osteoporosis in menopause.Materials and methods: There were 76 participants out of wich 36 women with DM2. Average diabetes duration was 14.48±10.51 years with mean HbA1c 7.8...

Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant familial tumor syndrome characterised by varying combinations of endocrine and non-endocrine tumors. Breast cancer is the most frequently diagnosed cancer in women, but presence of breast cancer in MEN1 is extremely rare.A 36-year-old patient has been diagnosed with primary hyperparathyroidism, breast cancer and hyperprolactinemia due to a pituitary macroprolactinoma. Treatment ...

Introduction: MTC originates from the parafollicular calcitonin secreting cells. One quarter of MTC patients have familial form of the disease with RET mutation.Case reports: First female patient underwent total thyroidectomy for MTC at the age 40. Further investigation showed elevated urinary catecholamine levels and MIBG scintiscan verified bilateral pheochromocytoma. Bilateral adrenalectomy was performed. On follow-up basal and stimulated calcitonin l...

The co-secretion of GHRH and GH has been described previously in a patient with GHRH producing pituitary somatotroph adenoma. Here we present a patient with MEN1 and ectopic secretion of both GHRH and GH from a neuroendocrine lung tumor.A 52-year-old woman was diagnosed in 2009 with two lung tumors, 4 cm right upper lobe tumor, and 2 cm left lower lobe tumor. Owing to a mild coarsening of facial features, acromegaly was suspected. Endocrine studies showe...