Endocrine Abstracts

Introduction: Leptin, adipose-tissue-derived hormone has a prominent role in bone remodeling by activating, through CNS relay, the sympathetic tone which inhibits bone formation. Schizophrenia is a CNS disease associated with low bone mass and changes in bone remodeling. Risperidone, atypical antipsychotic, may be related to increase in body weight (BW). Increased BW is thought to be protective to the bone.Aim: To determine relations between leptin, bone...

Primary hyperparathyroidism is an autonomous form of hyperparathyroidism, whose characteristics are: increased secretion of parathyroid hormone with clinical signs of hypercalcemic syndrome and various organ lesions, including bones.Case report: A 51-year-old Caucasian female presented with walking difficulties, polyuria, polydipsia, palpitations and headaches. Examination showed thoracic spine hyperkyphosis with consecutive chest deformity, staggered wa...

Introduction: The most common localization of parathyroid glands is behind the thyroid gland poles. According to different authors ectopic localization is present in 37–45.7%.Case report: Caucasian male, 31 years old, with elevated serum calcium was sent to an endocrinologist after pyelolithotothomy. He has the history of ulcerative colitis treated with anti-inflammatory therapy. Laboratory analysis: total serum calcium: 2.85 mmol/l, phosphorus: 0.6...

Introduction: By using insulin analogue, it is expected to improve glycemic regulation in poorly controlled type 2 diabetes (t2DM). The aim of the study was to examine the quality of glycemic control and quality of life (QoL) of patients managed with insulin analogues, previously treated with human insulin.Materials and methods: The pilot study included 30 t2DM outpatients, divided into two groups (15 subjects) – the first group was treated with hum...

Background and aim: Iron overload and inflammation might participate in the pathogenesis of insulin resistance in community. The improvement of insulin resistance in hemodialysis (HD) patients is frequently seen after correction of anemia. The aim of this study was to investigate the influence of recobinant humam erythropoietin (Epo) treatment on insulin resistance in non-diabetic HD patients.Patients and methods: We investigated the effects of 6 months-...

Introduction: Subclinical and clinical primary hypothyroidism potentially makes a negative influence on the patient’s quality of life. Present study examined the level of hypothyroid symptoms and signs expression as well patient’s quality of life before levothyroxine and after substitutionally-induced laboratory euthyroidism.Material and methods: Prospective case–control study consisted of 75 female patients divided into three groups based...

According to the novel concept bone remodeling is centrally regulated (CNS). Leptin the adipocyte derived hormone acts on hypothalamus and by increasing sympathetic activity acts on osteoblasts to regulate bone formation. In patients with schizophrenia several factors have influence on bone metabolism. Schizophrenia per se, as a disease of central nervous system is associated with increased occurence of osteoporosis. Hyperprolactinemia as consequence of antipsychotic tr...

Spontaneous subarahnoid hemorrhage (SAH) is a recently identified risk factor for hipopituitarism, especially growth hormone (GH) and corticotroph deficiencies. The aim of this study is to perform the initial screening procedure to identify the patients with increased risk of neuroendocrine dysfunction after SAH in the chronic phase and to identify the possible predictor(s) for neuroendocrine dysfunction. Ninety-one patients (30 males, 61 females), age between 19 and 69 years ...

Objective: Hyperthyroidism is accompanied by low bone mass. Because the reference range of TSH levels is defined statistically, some individuals with high-normal TSH levels (TSH <10 mU/l), may have mild hypothyroidism (subclinical hypothyroidism) and reduced bone mass. We therefore determined whether serum TSH levels correlate with bone mineral density (BMD) in persons with subclinical hypothyroidism.Design: A cross-sectional study.<p class="abst...

Ghrelin is a somatotrophic, orexigenic and adipogenic hormone that has an important homeostatic role by linking regulatory systems for growth and energy balance. Ghrelin- secreting neuroendocrine tumors are rare, but we had the opportunity to study a 71 years old female patient with a gastric ghrelinoma. The patient was submitted to gastroenterological examination after having episodes of diarrhea, and small subepithelial polyp (5 mm) was revealed on gastroscopy. Pathohystolog...