Endocrine Abstracts

Background: Duration of postoperative follow-up in patients with pheochromocytoma/paraganglioma (PPGL) is still not clearly specified. It is estimated that 5-year risk of a new events (metastatic/recurrent disease) after surgery is 27% in young patients, 25% in those with paraganglioma and around 10% in older patients and those with pheochromocytoma. Arterial aneurysms (AA) accompanying PPGL are described as complication/comorbidity that affects prognosis in these patients.</p...

Background: Serum paraoxonase-1 (PON-1) activity is decreased in clinical conditions associated with low high density-cholesterol (HDL-C), increased lipid peroxidation and low-grade chronic inflammation such as in type 2 diabetes mellitus (T2DM). Although many studies have shown that some poly unsaturated fatty acids (PUFA) modulate cardiovascular risk in T2DM, until now there is no data about the association of any fatty acid (FA) with PON-1 activity. This study aims to inves...

Sy Sheehan or postpartal pituitary necrosis presents with symptoms and signs of hypopituitarisms. It is usually a consequence of complicate delivery followed by intensive uterine bleeding. Diagnosis can be delayed years after delivery, up to 20 years.We present a case of 51-year-old female patient. She was admitted in the department of neurology in the Emergency center, Belgrade, with disturbance of consciousness. Few days before she felt leg weakness an...

Bacground: In type 2 diabetes mellitus (T2DM), the level of polyunsaturated fatty acids (PUFA), is usually decreased, and could be accused for metabolic disturbance, chronic inflammation, and accelerated atherosclerosis. The aim of this study was to determine if there is any relationship between composition of plasma phospholipids PUFAs and parameters of metabolic syndrome.Methods: The study was cross-sectional. Fifteen T2DM patients 63.22±7.20, BMI...

Introduction: Although intensive, repeated and perennial, physical stress of training generally does not represent a health hazard to professional athletes. Adaptation to such stress is presumed on multiple levels, but still not fully defined. Our aim was to analyze specificities of hypothalamic-pituitary-adrenal (HPA) axis response and adaptation to physical stress in professional athletes.Subjects and methods: We exposed 55 professional male athletes t...

Activation of hypothalamo-pituitary-adrenal (HPA) axis is a common feature of endocrine responses to stress, with cortisol secretion as an end product of this activation. Acute rise in cortisol level during stress is of utmost importance for metabolic adjustments, immune system adaptations, cardiovascular responses and muscle tissue remodeling. But since chronic hypercortisolism has many deleterious effects, scientific interest has started focusing around different biological ...

Introduction: Prolonged exposure to stress has a modifying effect on activity of hypothalamo-pituitary-adrenal (HPA) axis. This is a protective adaptation aimed to diminish potential deleterious effects of chronic hypercortisolism, and to diminish effects of acute exposure to heterotypic forms of stress. Our aim was to analyze modes of cortisol response to acute physical stress in groups of different stress categories and sex.Subjects and methods: Study ...

Aim of this study was to investigate head to head ACTH and cortisol responses to DDAVP and ghrelin in patients with CD. Study was approved by the local ethics committee and informed consent obtained. Nine patients with CD were submitted to ghrelin 1 μg/kg and DDAVP 10 μg bolus iv administration on two separate occasions. Blood was sampled at 0.15, 30, 45, 60, 90 min. for ACTH (ELISA) and cortisol (RIA, Cis, Bio International, France) measurements.<p class="abstex...

Anorexia nervosa (AN) is a product of complex interactions between physiological and psychological processes. Nausea, gastric pain and fullness are common features of AN patients. The aim of the study was to investigate the effects of therapy and psychological conditions on body weight restoration in patients with AN. In 21 AN patients (age 22.4±0.7 yrs) with gastric problems at low weight (BMI 15.9±2.3 kg/m2). oesophagogastroduodenoscopy with gastric biop...

Aim: There is a significant link between the increased activity of estrogen and its metabolites in endometrial carcinogenesis. Polymorphisms of the gene involved in metabolism of estrogen can modulate risk for the development of endometrial cancer. CYP1B1 plays an important role in estrogen metabolism. In our study, the frequency of three CYP1B1 gene polymorphisms (4326 C> G, 4390 A> G and 355 G> T) were studied in obese and non-obese women with endometrio...