Endocrine Abstracts

Background: Adolescent girls with type 1 diabetes (T1DM) have a higher incidence of metabolic risk factors like hypertension, dyslipidemia, non-alcoholic hepatic steatosis (NASH), abdominal adiposity and polycystic ovarian syndrome (PCOS) when compared with their non-diabetic peers. Moreover, metabolic risk factors seem to appear even in T1DM girls without overweight or obesity. We aimed to determine the prevalence of several metabolic risk factors in adolescent T1DM females, ...

Introduction: Cushing’s syndrome (CS) is a rare disease resulting from prolonged exposure to supraphysiological levels of glucocorticoids. Cushing’s Disease is the most frequent cause of endogenous CS. This disease has a broad spectrum of clinical manifestations and is associated with an increased morbi-mortality. Diabetes Mellitus (DM) and hypokalemic alkalosis affects up to 50 and 10% of CS patients respectively. Disease onset and severity reflects the magnitude of...

Objective: To investigate adherence to hormone replacement therapy (HRT) in patients with hypopituitarism in a tertiary center outpatient clinic.Patients and methods: Prospective, cross-sectional study of patients with hypopituitarism on HRT for at least two pituitary deficiencies (independent of diabetes insipidus). Medication adherence was assessed using a validated Portuguese version of four-item Morisky scale, in which participants were asked to indi...

Functional hypogonadism has been described in association with acute severe medical or surgical illness, subacute recovery and chronic disease. We present a case of transitory hypogonadism manifested during a peri-surgical period. A 42-year-old patient was sent to the endocrinology clinic due to hypertension and a solitary adrenal mass. He was treated with bisoprolol and telmisartan, that he maintains until today. The evaluation favoured non-functional adenoma but during the f...

Introduction: Amiodarone is a well-established antiarrhythmic drug frequently used in tachyarrhythmias. Side effects include hypothyroidism and hyperthyroidism. Extreme cases such as myxedematous and thyrotoxic crisis are very uncommon. Here we report one case of each of these presentations.Case Report no.1: A 73-year-old woman with history of atrial fibrillation under treatment with amiodarone presented to the emergency department with headache, nausea ...

Graves’ disease is the most common cause of hyperthyroidism in non-endemic areas and antithyroid drugs are the preferred first-line therapy in many centers. The aim of this retrospective investigation was to verify the association of remission with the achievement of normal TSH and free-T4 during the first 18 months of treatment and to compare it with negative anti-TSH-receptor antibodies at 18 months, a marker with known prognostic value. All patients diagnosed with Grav...

Background: Struma ovarii (SO) is the presence of thyroid tissue as a major cellular component in an ovarian tumour.Case report: A 35-year-old, Caucasian female, asymptomatic and with normal physical examination was submitted to left oophorectomy due to an ovarian mass (8.2×7.0×6.0 cm) detected in routine pelvic examination. Her mother also had history of oophorectomy for an ovarian tumour and partial thyroidectomy for benign thyroid nodule. Th...

Introduction: Regional lymph node (LN) metastases have prognostic significance in differentiated thyroid cancer (DTC). Several studies demonstrated that lateral neck LN metastasis, classified as N1b, have a greater impact on overall survival than central LN metastasis. Our study aimed to assess the risk of N1a vs N1b involvement on outcome in patients with differentiated thyroid cancer (DTC), according to the 7th edition of the TNM staging system.Methods...

Introduction: Regarding thyroid nodules, in case of follicular lesion of undetermined significance (FLUS), performing repeat fine-needle aspiration (FNA) is a common follow-up strategy. It has been suggested that a waiting period of at least 3 months between FNAs would increase the diagnostic yield. Our study aims to clarify the optimal time for repeat FNA in case of an initial FLUS result.Methods: We identified retrospectively all thyroid FNA FLUS resul...

Introduction: Cushing’s syndrome (CS) has been related to higher psychopathology. Psychopathology can be related to poor memory performance, and low quality of life. The aim of this study is to establish the relationship between the three parameters and with subjective symptom perception in CS.Methods/design: Thirty six patients in remission of CS and 36 matched controls for age, sex and education years were included in the study. They completed SCL...