Endocrine Abstracts

Context: Cushing’s syndrome (CS) is a rare endocrine disease, due to cortisol hypersecretion. CS patients have several comorbidities, often still present after biochemical cure. There are no specific nursing healthcare programs to address this disease and achieve improved health related quality of life (HRQoL). Thus, an educational nursing intervention in these patients, through the development and promotion of specific educational tools, appears to be justified.<p cl...

Introduction: Adequate glycaemic, along with other cardiovascular risk factor control in type 2 Diabetes (T2D), and its beneficial impact on subclinical inflammation is associated with better microvascular outcomes.Objectives: To analyse the correlation between glycaemic control adequacy and systemic inflammatory markers, renal disease progression and cardiovascular risk factors.Material and methods: Retrospective cohort observatio...

Recent evidence shows that are modifiable risk factors and preventable, the most responsible for the high morbidity and mortality secondary to multiple chronic conditions (MCC), and smoking is one of the most important representatives. However, we still lack studies of populations with MCC and its association with smoking status.Objectives: To identify clinical and psychosocial characteristics according to the status of smoking among users with MCC, at h...

Introduction: Graves’ ophthalmopathy (GO) varies from minor changes to visible face disfigurement which may compromise the visual capacity and the aesthetics of the patient. These deformities affect the quality of life in both functional and emotional senses. There are some questionnaires designed to evaluate the patient’s health, quality of life and relationship with a specific disease. The use of these questionnaires is recommended to improve the quality of care an...

Introduction: Hypercortisolism in Cushing’s syndrome (CS) determines increased mortality and morbidity. Hypercortisolism is also present in chronic depressive disorders and stress, where telomere length (TL) is shorter than in controls. We hypothesized that telomere shortening may occur and contribute to premature morbidity in CS.Aim: Investigate TL in CS compared to matched controls, and longitudinally in a subset of CS patients evaluated both with...

Introduction: Cardiovascular changes are rare but life-threatening consequences of primary hyperparathyroidism.Case report: A 53-year-old man, with past and family history of peptic ulcer, presenting with coronary heart disease and ischemic and dilated cardiomyopathy, treated with cardiac resynchronization. He was admitted to the emergency room due to sustained monomorphic ventricular tachycardia (MVT). Laboratory tests revealed primary hyperparathyroidi...

The use of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG–PET) has increased the detection of thyroid incidentalomas (TI). These are associated with a risk of malignancy between 25 and 50%. Some studies show an association between SUVmax uptake and malignancy.The objective of this study was to determine the prevalence of malignancy on 18F-FDG–PET positive thyroid nodules and to evaluate the relatio...

Introduction: In singleton pregnancies, gestational diabetes mellitus (GDM) results in an increased risk for maternal and neonatal complications. In twin pregnancies, however, the effect of GDM on maternal and neonatal complications appears to be different in comparison to singletons. The few studies that investigated the consequences of GDM in twin pregnancies are small and present conficting evidence, with some finding no difference in perinatal outcomes between GDM and non-...

Background: Residual C-peptide (CP) secretion has been associated with better glycemic control in patients with type 1 diabetes (T1D).Aim: To evaluate how residual fasting CP (fCP) secretion impacts glycemic control in T1D and to identify possible confounding factors.Methods: A retrospective analysis of adult patients with T1D followed in our department that had their fCP and glucose levels obtained on the same blood sample during ...

Background: The use of Flash Glucose Monitoring (FGM) for the management of type 1 diabetes mellitus (T1D) is rapidly increasing.Aims: To assess the longitudinal evolution of glycated haemoglobin (HbA1c) and body mass index (BMI) with the use of FGM in patients with T1D; to determine predictive factors of benefit with the use of this technology.Materials and methods: Retrospective study of T1D patients, using FGM ≥6 months an...