Endocrine Abstracts

Tc-99m sestamibi (MIBI) imaging is able to localize parathyroid adenomas/carcinomas in patients with primary hyperparathyroidism. Brown tumours are one of the skeletal manifestations of long standing hyperparathyroidism and its incidence has been reported to be 3%. Radiological features of these tumors may mimic bone metastasis. There are only a few reports showing brown tumours uptake in the whole-body Tc-sestamibi scan.We report a 72-year-old female wi...

Abstract: Radioiodine is a definite treatment option for toxic goiter. We have evaluated volume reduction, function and autoimmunity outcomes with a 15 mCi fixed regimen. Patients with at least one US evaluation before and after Iodine-131 therapy and with at least one year of follow-up were included. TSH, free-T4, antibodies and goiter volume before and yearly after Iodine-131 treatment were analysed for the length of the entire follow-up. The total 151 patients, 72.6% female...

Background and aims: Rickets is a childhood condition resulting from impaired mineralisation of the growth plate, resulting in bony deformities. A retrospective survey was undertaken to identify causes of rickets in children treated at the Royal Manchester Children’s Hospital from 2009 to 2014.Methods: Cases of rickets were identified through a search of all paediatric radiology reports containing the words ‘Rickets’ or ‘Osteomalacia&...

Persistent Mullerian duct syndrome (PMDS) is a rare disorder of sex development characterized by the persistence of Mullerian duct derivatives in a genotypic (46,XY) and phenotypic normally virilised male. PMDS is transmitted in an autosomal recessive manner, caused by mutations in the anti-Mullerian hormone gene or in the gene encoding the AMH receptor. The authors report a case of a male patient aged 62 years, with bipolar disorder, referred to the endocrinologist by inciden...

Background and aims: Maternal BMI and weight gain are associated with maternal and fetal complications in gestational diabetes (GD), but their relative contribution is not clearly defined. Our aim was to determine the influence of BMI and weight gain in the evolution of GD.Material and methods: Multicenter, retrospective study of women diagnosed with GD at the medical centers of the Portuguese Group for the Study of Diabetes and Pregnancy in 2011. We use...

Background: The Cushing’s disease (CD) is associated with comorbidities that have a significant impact on patients’ quality of life. However, it is not known the true impact of the disease remission on these comorbidities.Objectives: To assess the evolution of comorbidities associated with CD, after its remission.Methods: It was done an observational, analytical and retrospective study of patients with CD in remission, fo...

A 30-year-old male was admitted to the neurotraumatology ward after head trauma with cerebral concussion, subdural & subarachnoidal haemorrhage. The Endocrinologist was called to evaluate high urinary debits. The patient was healthy until 4 years before admission. He enrolled on variate patterns of alimentary restriction that resulted in the loss of 28 kg. Since then he had visited multiple doctors (Cardiology, Haemathology, Psychiatry, Gastroenterology, Urology, Endocrino...

Introduction: Type 1 gastric endocrine tumors (T1-GET) incidence is increasing world while mainly due to widespread use of upper endoscopy. Autoimmune disease (AID) is the hallmark of T1-GET, pernicious anemia is often found at presentation. Association with lymphocytic thyroiditis (LT) has been described.Aims: Retrospective evaluation of GET data from patients (pts) followed at IPO-Porto, including the presence of other AID with emphasis to LT.<p cl...

Background: Craneopharygioma is a rare solid or mixed tumor, that arise from remnants of Rathke’s pounch. Usually they are in the suprasellar region and very few of them arise from the sella. Bimodal (5–14 years old and 50–75) and slow growth are typical characteristics as well.Clinical case: A 20 years old boy was refered to endocrine clinic by hypothyroidism, hypotension, and sexual dysfunction. Central hypothyroidism, hypogonadotropic h...

Introduction: Acromegaly, a rare disorder resulting of tumor GH excess, is frequently associated with prognathism and facial dysmorphia. Characteristics and mechanisms responsible for the malocclusion and the craniofacial changes in acromegalic patients (ACR) are not clarified.Aims: To evaluate the craniofacial changes in an acromegalic group.Methods: We observed 59 individuals, 33 with ACR and 26 controls with nonfunctioning pitui...