Endocrine Abstracts

Background: Hypomagnesemia is common in patients with diabetes; possibly due to higher renal magnesium excretion in those patients. Hypomagnesemia seems to correlate with poor glycaemic control. The relationship between urinary magnesium (UMg) and glycaemic control is not known. We aimed to study the association between UMg and glycaemic control in a type 1 diabetes (T1D) pediatric population.Methods: Study of a pediatric population with T1D attending th...

Introduction: Hypogonadism is common and occurs prematurely in human immunodeficiency virus (HIV)-infected men, being hypogonadotropic hypogonadism (HH) more frequent. However, HH with very low testosterone has not been described. We present three HIV-infected men with severe HH and normal pubertal development.Case report: Three HIV-infected men, with HIV-1 diagnosis at the ages of 22, 34 and 35 years. Two of them had depressive syndrome, one treated wit...

Introduction: Hyperglycemia (irrespective of the presence of diabetes) has been associated with worse outcomes in hospitalized patients with a variety of diseases, namely critical illness. It is been recently proposed that a relative hyperglycemia – Stress Hyperglycemia Ratio (SHR) – might be even better associated with disease outcomes. We studied how SHR correlated with various morbidity parameters in hospitalized patients due to acute pyelonephritis.<p class="...

Introduction: Spontaneous fertility in Turner syndrome (TS) is rare, due to low or absent ovarian reserve. A greater number of ovarian follicules is present in the cases of gonadal mosaicism, although the accelerated pace of apoptosis remains. Thus, the early referral to reproductive counseling is advisable, ideally soon after diagnosis. The criopreservation of oocytes is one of the options for fertility preservation. The authors present a series of 7 patients with TS admitted...

Background: Amiodarone is an antiarrhytmic drug used mainly in atrial fibrillation. Amiodarone-induced thyrotoxicosis (AIT) is less common than hypothyroidism, but it represents a true therapeutic challenge. AIT can be due iodine load (type 1) or a destructive thyroiditis (type 2).Methods: Retrospective study of patients with AIT, diagnosed between 2010 and 2015, in a central hospital. We reviewed medical records regarding age, gender, amiodarone therapy...

Background: Fine-needle aspiration (FNA) is an important test for triaging patients with thyroid nodules and differentiating benign from malignant disease. According to Bethesda System Classification, the rate of AUS/FLUS is between 3–6% of all FNA. The malignancy risk is of 5–15%. TSH levels might be associated to the likelihood of malignancy in thyroid nodules according to some studies. Our aim was to establish a possible correlation between TSH level and malignanc...

Introduction: Follicular tumours of the thyroid gland include benign follicular adenomas, follicular carcinomas and the follicular variant of papillary carcinoma. Although, molecular markers are a promising area of research to differentiate thyroid neoplasms, there is ample room for improvement in the research and clinical applications in this field. Furthermore, the final diagnosis requires thyroid lobectomy. The present study examined whether a differential protein expressio...

Introduction: The Bethesda System for Reporting Thyroid Cytopathology is the standard for interpreting fine-needle aspiration (FNA) and created a new diagnostic category (III): ‘atypia of undetermined significance/follicular lesion of undetermined significance’ (AUS/FLUS). The risk of malignancy for this category has been ascribed of 5–15% but the real malignancy rate remains unclear and plays a key role to define appropriate management.Ob...

Introduction: Brain-derived neurotrophic factor (BDNF) is a protein that has been linked to several cardiovascular risk factors and bone status. Stress and corticosteroid exposure can affect BDNF levels, although this has never been studied in Cushing’s syndrome (CS). The aims of this study were to establish if BDNF levels were reduced in CS and to check possible associations to cardiovascular risk factors and bone status.Methods: 52 patients (18 ac...

Introduction: Intraoperative identification of neck lesions in patients who have undergone previous neck surgery is particularly difficult, because of operative scarring and distorted anatomy. Radioguided occult lesion localisation (ROLL) involves the preoperative intratumoral ultrasound-guided injection of a radioactive tracer. In the present study, we investigated the efficacy of roll in two patients with papillary thyroid cancer (PTC) who underwent previous neck exploration...