Endocrine Abstracts

Introduction: The prevalence of Transgender individuals seeking gender affirming hormone therapy (GAHT) has been increasing. It is important to closely monitor this therapy in order to minimize the risk of adverse effects.Aim: To evaluate the safety and monitoring of the GAHT in the Portuguese adult transgender populationMethods: Cross-sectional study conducted in March 2021. Data collected through an online questionnaire ...

After almost 3 years since SARS-CoV-2infection was detected for the first time, knowledge about its repercussions on the thyroid gland function in the course of acute illness or in the post-COVID-19 are still poorly understood. This gland may be particularly susceptible to SARS-CoV-2 as this coronavirus enters cells through ACE-2 receptors, which are largely expressed in the thyroid gland. Through an observational, longitudinal and retrospective study, we investigated the seru...

Mitochondrial diseases are rare conditions with a wide phenotypic range. The inability of dysfunctional mitochondria to produce sufficient ATP results in multi-organic defects dependent on high aerobic such as pancreas. The most common endocrine disease related to mitochondrial diseases is diabetes mellitus and it is thought to be secondary to insulin deficiency. A 26-year-old pregnant patient with 26 weeks gestational age was referred to an Endocrinology appointment ...

Introduction: Hyperandrogenism is a relatively common medical condition, however severe post-menopausal hyperandrogenism should raise suspicion of a malignant etiology and prompt clinical evaluation. Furthermore, androgen excess has also been associated with severely decreased quality of life. As such, identification of its cause and adequate treatment should not be delayed.Case Report: We report a case of a 66-year-old woman, who had a 5-year history of...

Introduction: Oestrogen receptors (ER) are essential for reproductive function and fertility. ER46 is a 46 kDa truncated isoform of full length ERα (ER66) that binds oestradiol (E2) and can signal via nuclear or membrane-initiated signalling pathways. ER46 has been detected in breast cancer cell lines but expression in endometrial tissues has not been documented. The aims of this study were a) to determine whether endometrial cells express ER46, and b) to investigate a po...

Background: Conventional treatment of X-linked hypophosphataemic rickets (XLH) involves administration of oral phosphate and vitamin D analogues. Newer therapies such as Anti Fibroblast Growth Factor 23 antibodies (burosumab) have now become available. An important treatment goal is to heal rickets; assessed by normalisation of serum alkaline phosphatase (ALP) levels and resolution of radiological signs of rickets.Objectives: (1) Assess disease severity ...

Introduction: Hypocalcaemia is a rare and potentially reversible cause of cardiomyopathy. Restoration to normal serum calcium levels usually leads to rapid improvement of cardiac function.Case report: A 42-year-old woman with a history of total thyroidectomy, due to large nodular goiter in 2016, and acute pos-operative hypoparathyroidism, assumed to be transient, with no supplementation since early 2017. In September 2018 she was admitted due to acute ca...

Introduction: Multiple endocrine neoplasia type 1 syndrome (MEN1) is a hereditary autosomal dominant disorder caused by germline mutations in the MEN1 tumour-suppressor gene and is typically characterized by parathyroid adenomas, duodenopancreatic neuroendocrine tumors (NETs) and pituitary adenomas. Breast cancer has recently been identified as manifestation of MEN1 and female patients have early onset elevated breast cancer risk.Case report: Female pati...

Background: Assessment of response to therapy is a valid tool for dynamic risk stratification in patients with differentiated thyroid cancer (DTC). It is well documented in patients treated with total thyroidectomy and radioiodine ablation therapy (RAI), but data is still sparse regarding patients treated with lobectomy. Our study aimed to evaluate response to therapy in patients with DTC treated with lobectomy.Methods: We performed a retrospective study...

Introduction: Vitamin D is a hormone that acts through the Vitamin D receptor (VDR) not only on the skeletal system but on a great number of target tissues, including thyroid gland. In recent years the association of vitamin D with autoimmune thyroid diseases (AITD), has been suggested.VDR gene polymorphisms had been associated with an increased risk of AITD. In addition a recent meta-analysis showed that AITD patients had lower level of 25-hydroxyvitami...