Endocrine Abstracts

Introduction: Proton magnetic resonance spectroscopy (1H-MRS) is a sensitive, non-invasive imaging technique capable of measuring brain metabolites in vivo. Chronic exposure to endogenous hypercortisolism in Cushing’s syndrome (CS) is associated with negative effects on memory and hippocampal volumes, even after biochemical cure.Objective: To investigate metabolites in the hippocampi of CS patients and controls, using 1</sup...

Introduction: Type 2 diabetes mellitus (T2DM) is a chronic disease, with prevalence increasing worldwide and its complications are major causes of early morbidity and mortality. Recent guidelines suggest the individualisation of glycaemic targets and glucose-lowering therapies.The aim of this study was to determine the quality of care provided to type 2 diabetic patients in our institution, analysing metabolic control, cardiovascular risk factors and pre...

Introduction: Bariatric surgery has proved to be effective in the management of morbid obesity. Our purpose was to compare the results obtained with adjustable gastric banding (GB) and Roux-en-Y Gastric Bypass (RYGB) during 2 years of follow-up after surgery, with regard to anthropometric parameters and related comorbidities.Methods: We evaluated prospectively patients who underwent GB and RYGB between 2004 and 2010 and compared the evolution of anthropo...

Obesity leads to low-grade inflammation, and high-fat diet is one of the major causes. On the other hand, menopause can aggravate it by promoting food intake alterations, and metabolic and endocrine adaptations. Thus, we used ovariectomized rats fed with high-fat diet to evaluate changes on the tissue inflammatory state. Forty days-old female Wistar rats were fed with: a hyperlipidic diet enriched with lard – H-group; or chow diet – C-group; for 30 days. After this p...

Connexins are a proteins critically involved in the formation of gap junction, which connect cells with each other and enable the exchange of small compounds and, besides having a role independently of gap junction formation. At least, in the anterior pituitary two cellular networks have already been identified, one of them is composed of the endocrine inactive folliculo-stellate cells and the second one is the GH-producing somatotroph cell network. It is supposed that gap jun...

Introduction: Primary thyroid lymphoma (PTL) is responsible for 0.6–5% of all cases of thyroid cancer and less than 2% of all extranodal lymphomas. PTL is more common in elderly women and are commonly of B-cell origin. Current treatment regimens for PLC consist of chemotherapy and external beam radiation. Surgery plays an important role, including the control of symptoms in large obstructive lymphomas.Aims and methods: Retrospective data review of p...

Introduction: Malignant toxic thyroid nodules are rare, with few cases described in the literature. The prevalence of malignancy in toxic adenomas varies between 1 and 8% in different series (most, corresponding to <2.5%). For that reason, international guidelines recommend that they should not be submitted to fine needle aspiration biopsy.Case report: A 42-year-old female patient without relevant previous medical history was admitted to our hospital...

Studies have demonstrated that ATP-sensitive potassium channel (KATP) subunits SUR2A (sulfonylurea receptor) and KIR6.2 are involved in glucose uptake into skeletal muscle. It is known that the glucose transporter 4 (GLUT4) expression is highest in oxidative type I fibers, pointing out the important role of oxidative muscles as glucose uptakes. Considering these aspects the aim of this study was to investigate whether KATP channel can influence glucose uptake in oxidative musc...

Aims/hypothesis: Several data have shown the association between diabetes type 2 (DM2) and transcription factor 7-like 2 (TCF7L2) gene polymorphisms, in several and different ethnical populations. Although the pathophysiology is not completely clear, it seems that beta and alpha cell functions are abnormal. Up to these days there is no clinical data showing association between TCF7L2 gene polymorphism allele rs7903146 T and beta cell insulin and C-peptide contents in DM2 patie...

Background: Nonfunctioning pituitary adenomas are commonly diagnosed as large tumors. Most are detected incidentally during imaging studies. The aim of this study was to evaluate clinical presentation, characteristics and outcome of nonfunctioning pituitary macroadenomas incidentally (NFPMI) discovered.Methods: Twenty-seven patients (mean age 58.9 years, 45–82; 18 males:9 females) with NFPMI were studied. They represent 13.1% of NFPM followed in our...