Endocrine Abstracts

Introduction: Struma ovarii is a rare form of ovarian teratoma mostly composed of thyroid tissue. In about 5% of the cases, well-differentiated thyroid carcinoma may arise in struma ovarii. As this medical entity is so exceptional, there is still no consensus on diagnosis and treatment.Case Reports: A 52-year-old old woman was submitted in 2009 to total hysterectomy with bilateral adnexectomy and pelvic lymphadenectomy. Histopathology r...

Introduction: Eating habits may contribute to longevity. Consumption of red meat, source of saturated fatty acids and cholesterol may be associated with increased risks of diabetes, cardiovascular disease (CVD), and mortality risk.Methods: We studied 521 subjects, both genders, 253 centenarians (CENT) (100.26±1.98 age) and 268 controls (67.51±3.25 age), both low (LCR) and high cardiovascular risk (HCR), calculated based on QRISK®2-2016. An...

Introduction: Although thyroid nodules (TN) are less common in children than in adults, the risk of malignancy is much higher in pediatric age and therefore representing greater concern in this age group.Objective: Evaluate a cohort of pediatric patients with TN and search differences between subjects with malignant and benign TN regarding sex, age, compressive symptoms, cervical ultrasound characteristics, family history of differentiated thyroid cancer...

Introduction: Estimated prevalence of hypertension (HT) in Portugal is 42%. It is a major risk factor for coronary heart disease and cerebrovascular disease, the leading mortality cause in Portugal. Primary aldosteronism (PA) was once recognized as rare cause of secondary hypertension and hypokalemia a condition present in all cases. Nowadays, prevalence of this condition is about 10% in HT patients, being the commonest form of secondary HT. Secondary forms of HT should be exc...

Background and aims: Hypoglycemia is a common complication of diabetes treatment and it’s associated with poor outcomes. A link between severe hypoglycemia and renal dysfunction was suggested. No studies evaluated the impact of hypoglycemia of inpatients in microvascular or macrovascular complications. The aim of our work was to study the evolution of renal function between admission and final visit, and the impact of nephropathy in the presence of hypoglycemia in inpatie...

Introduction: During childhood and puberty, growth hormone(GH) is essential for linear growth. Consequently, children with isolated GH deficiency(GHD) must receive replacement therapy. GH has also important metabolic actions. GHD in adults is associated with altered body composition. However, long-term consequences of GH treatment in adults is not sufficiently known.Objective: To evaluate GH treatment during pediatric age in patients with isolated GHD.</...

Introduction: Testosterone treatment in patients with hypogonadism has been associated with cardiovascular and prostatic complications.Objective: To describe the evolution of analytical parameters associated to the complications of testosterone treatment in a male population with hypogonadism treated with testosterone. Methods A retrospective, longitudinal study in which the clinical data of male adults with hypogonadism under intramuscular testosterone ...

Introduction: Amiodarone is an antiarrhythmic iodine-rich drug, known to induce thyroid dysfunction both due to its high iodine content and through amiodarone-induced thyrotoxicosis (AIT), being this latter process classified into three different types. Type 1 is associated with increased thyroid hormone synthesis; type 2 is a destructive process with thyroid hormone release and type 3 is thought to be a mixture of the former two. Since treatment options are different, there h...

Background: Takotsubo cardiomyopathy is a rare, acute, nonischemic cardiomyopathy causing transient systolic disfunction of the apical and/or mid segments of left ventricle and is commonly associated with emotional and physical stress. Thyrotoxicosis is a rare cause of this condition, resulting from direct and indirect action of thyroid hormones on the cardiovascular system.Case presentation: A 43-year-old woman presented at emergency room with chest pai...

Hashimoto’s thyroiditis (HT) is the most common chronic autoimmune thyroid disease, which is characterized by alteration of the thyroid function. HT is a multifactorial disorder and several candidate genetic loci have been identified as contributing to HT. The transcription factor Nrf2, encoded by the NFE2L2 gene, is an important regulator of the cellular protection against oxidative stress. The relevance of selenoproteins in follicular thyroid cell physiology and in mole...