Endocrine Abstracts

Introduction: Graves’ disease is the leading cause of hyperthyroidism in the adult population. Antithyroid drugs (ATD) are the first choice worldwide, however, after an initial treatment course of 18-24 months, almost 40-50% will relapse. In these cases, current guidelines suggest a second course or prolonged use of ATD as an option. Recently, the study of quality of life (QOL) has obtained great importance, since the QOL in hyperthyroid patients is very affected. However...

Introduction: Incidence of Digestive NETs (DNETs) has increased in the last 40 years. Visceral obesity, metabolic syndrome (MetS) and insulin resistance (IR) have been associated with several types of cancer.Aim: To evaluate possible associations of obesity, hyperinsulinemia and IR with well-differentiated (WD) DNETs through a case control study.Materials and methods: Ninety-six patients with gastrointestinal (75.0%) and pNET (22.9...

Introduction: Immunossupression is a possible consequence of hypercortisolism, putting these patients in a state of increased risk of infections.Case report: Female, 19 years old. In July 2014 she seek for medical care because she became feverish and developed an erythematous rash on her face/trunk with subsequent widespread to the entire body. She was admitted in the ICU with the diagnosis of severe varicella with acute cholestatic hepatitis and conflue...

Metabolic liver dysfunction can be a causative factor for morbity and mortality in Berardinelli–Seip syndrome patients. We evaluated hepatic function in 29 Berardinelli–Seip patients. Diabetes mellitus (DM) was present in 23 of them. We analyzed biochemical parameters including AST, ALT, GGT, ALP levels and liver non invasive imaging aspects. The liver was graded as normal, mild, moderate, or severe hepatic steatosis.Results: We could not find ...

The association of hyperandrogenism and insulin resistance is common in several syndromes. The proposed mechanism is the stimulation of ovarian theca cells by insulin to produce testosterone. Weight loss, improves insulin resistance, reduces insulin levels and consequently decreases circulating androgens.Material and methods:Ten female subjects with severe obesity and hyperandrogenism were evaluated before and after weight loss at...

IntroductionSimultaneous pancreas-kidney transplantation (PKT) has a beneficial effect on the evolution of chronic complications in type 1 diabetic (T1D) patients with terminal chronic kidney disease (CKD). However, the CKD-mineral and bone disorder (CKD-MBD) remains a frequent complication. There are a few studies addressing the long-term evolution of bone mineral density (BMD) in these patients.AimTo charac...

Introduction: Primary aldosteronism (PA) is a rare but underestimated cause of hypertension. PA has been associated with increased risk of malignancy through mechanisms involving up-regulation of the renin angiotensin system (RAS) promoting an enzymatic cascade influencing carcinogenesis. Recently, Microwave Ablation (MWA) has been established as an effective and safe minimal invasive treatment for Conn’s Disease.Aim: The authors present four clinic...

Introduction: The best timing for PRRT (peptide receptor radionuclide therapy) in the case of pancreatic neuroendocrine tumors (panNETs) is still to define, as randomized prospective trials are lacking. Recent studies suggest that some systemic therapies can affect response to PRRT, favoring an earlier use of the latter.Objective: To determine the efficacy and toxicity of PRRT, comparing its results when used as a second line systemic therapy (a...

Background: Pheochromocytoma (PHEO) is a rare neuroendocrine tumour, classically presenting with hypertension, palpitations and headaches. Some patients have atypical presentations. We report a case of Myocardial Infarction with non-obstructed coronaries (MINOCA) as the key to unravel the diagnosis of PHEO.Clinical case: A 53-year-old man with type 2 diabetes mellitus and hypertension (under gliclazide MR 60 mg id, bisoprolol 5 mg id, ramipril 5 mg id an...

Neuroendocrine neoplasms (NENs) arise from specialized cells called neuroendocrine cells spread through the body, mainly in the gastrointestinal tract, pancreas and lung. Pathological classification of Lung NENs include well differentiated NENs, that can be classified as typical or atypical carcinoids, and poorly differentiated neuroendocrine carcinomas (NECs), classified as small-cell lung carcinoma (SC-NEC) or large-cell neuroendocrine carcinoma (LC-NEC). We present a case o...