Endocrine Abstracts

Many (40%) patients with medullary thyroid carcinoma (MTC) are cured after initial surgery, others may survive for decades despite persistent disease, and few patients with advanced disease (estimated annual incidence in France: 50 cases) may require novel therapeutic modalities. An activating RET mutation is found in all hereditary MTCs and in half of sporadic MTCs, and is believed to be responsible for the neoplastic transformation of C-cells and for their development. Drugs...

The standard approach to in vitro fertilisation is ovarian hyperstimulation to provide multiple oocytes, which ultimately provides greater choice of embryos, but multiple pregnancy and the complication of ovarian hyperstimulation syndrome (OHSS) have been consequences. Single embryo transfer (SET) has been successfully used voluntarily in Scandinavia and regulatory restriction is becoming more effective in many countries. Having a smaller number of oocytes following milder sti...

Introduction: Various imaging modalities are used in the preoperative localization of insulinoma. CT is the modality that is in widespread use. Endoscopic ultrasound (EUS) allows the transducer to be placed in close proximity to the pancreas, thereby yielding images of higher quality, leading to accurate localization. An accurate preoperative localization results in a minimal invasive surgery and less occurrence of residual tumors, translating into a better clinical outcome. O...

Aims: Type 2 diabetes (T2DM) now affects a significant proportion of young people worldwide. ‘X-borough’ contains a strikingly young, diverse population with one of the highest rates of prevalence for adult T2DM in the UK. Our aims were to determine the prevalence and examine the characteristics of young people with T2DM in this population.Methods: Forty-four young people (<25 years) with T2DM were matched with an equal number of young peop...

We found that mast cells were present in pubertal mammary glands, and hypothesized that they participate in mammary morphogenesis and are sensitive to IGF1, which is essential for mammary development.As independently reported in another model of mast cell deficiency (Developmental Biology 2010 337 124), mast cell-deficient W/Wv mice had significantly less terminal end buds and ducts and smaller gland areas than controls at 3, 6, ...

Dizygotic twinning is the result of fertilization of multiple follicles that develop during one ovulatory cycle. Significant factors contributing to natural DZ multiples are heredity, increased maternal age and higher parity. Older women are at higher risk for DZ twinning because they have a strongly increased risk of multiple follicle growth as a result of diminished ovarian feedback from the due to a smaller available cohort of follicles. FSH increases allowing all follicles...

Introduction: Faster decline in serum thyroid hormone levels in hyperthyroidism is seen adding cholestyramine at conventional treatment in some studies (1.2).Design/methods: Retrospective controlled study. Follow-up: ±3 weeks.Patients with hyperthyroidism: 17 treated with antithyroid drugs (mean dose 35 mg/day) combined with cholestyramine (mean dose 12 g/day).Control group: 23 only treated with antithyr...

Introduction: The ectopic thymus tissue (ETT) represents a migration and descending deficiency of the organ during embryogenesis.HMWK have a strong positive reaction in normal anatomical localized thymus and thymomas. A similar reaction pattern is seen in thyroid solid cell nests (SCNs) suggesting that these cells share a common origin with thymic tissue. Moreover, can be very helpful in differentiate CASTLE from other thyroid tumors.<p class="abstex...

Introduction: Elastography is a new dynamic technique that uses ultrasonography for the assessment of tissue stiffness. The principle of ultrasound-elastography is that compression of the examined tissue induces a smaller strain in hard tissues than in soft ones. Until now elastography has been applied to study the hardness and elasticity of thyroid nodules, aiming to differentiate malignant from benign ones.Aim: We decided to study if ultrasound elastog...

Introduction: Papillary thyroid microcarcinoma (PTMC) is defined as a papillary thyroid cancer measuring 10 mm or less in greatest dimension. Diagnosis of PTMC could be established during the surgery for benign thyroid lesions and after fine needle aspiration biopsy. Despite the small size, PTMC could be highly aggressive tumor showing metastases and elevated invasiveness. However, correlation between tumor size and risk of lymph-node metastases remains unclear.<p class="a...