Endocrine Abstracts

PurposeChildhood-onset craniopharyngiomas (CP) are diagnosed due to clinical symptoms (symCP) or incidentally (incCP). We investigated clinical manifestations and outcome in incCPs and symCPs.MethodsIncCP were discovered in 4 (3m/1f) and symCP in 214 (101m/113f) CP recruited 2007–2014 in KRANIOPHARYNGEOM 2007. Age, sex, height, body mass index (BMI), tumor volume, degree of resection, pre- and postsurgic...

Men with spinal cord injury (SCI) exhibit a prostate volume significantly smaller compared to age-matched able-bodied men1–3. As men with chronic SCI (lasting more than 1 year) also display a very high prevalence of androgen deficiency4,5, a protective role of low testosterone against prostate enlargement could be hypothesized in this population. This study aimed to identify independent determinants of prostate volume in men with chronic SCI. As ass...

Brown tumors represent a late-stage bone change caused by primary hyperparathyroidism, presenting in only 2–3 percent of the cases. Therefore as primary manifestations there is even a smaller percent. The common sites of brown tumor are the long bones, ribs, clavicle or pelvic girdle. The solitary palate brown tumor as initial presentation of a primary hyperparathyroidism is rare and often accompanied by tumors of other facial bones. We present the case of a 67 year old w...

The T2-weighted characteristics of GH-secreting pituitary adenomas have recently received particular attention from the research community. It now appears that somatotropinomas can be divided into groups with different behavior according to their T2-weighted signal. T2-hypointense adenomas are generally smaller, invade the cavernous sinus less frequently and are responsible for higher levels of GH-hypersecretion (Fig. 1). Treatment with somatostatin analogues, both before and ...

Background: Radiofrequency ablation has recently been used for the treatment of benign thyroid nodules, with outstanding results. However, in most related studies, smaller nodules (<2 cm) were included and the procedure was usually performed by a radiologist or surgeon. Therefore, this study evaluated the efficacy and safety of radiofrequency ablation for nodules >2 cm performed by an endocrinologist with several years of experience performing fine-needle aspiration cy...

Introduction: The pituitary adenoma is the most frequent begnin pituitary tumor. They are labeled based on their size, tumors smaller than 1 cm called microadenomas and tumors bigger than 1 cm called macroadenomas. Moreover, they can be functional or non functional. Among the functional ones, gonadotroph adenomas represent 15 to 20%.ObservationWe report the case of a 27 years old women, who consulted for secondary amenorrhea for 1 ...

Introduction: High BMI has been associated with an increased risk for breast cancer among premenopausal and postmenopausal women. Several biological mechanisms play a significant role in the genesis and progression of breast cancer.Material and methods: This study aimed to investigate relationship between BMI and breast cancer diagnosis or progression in a Croatian population. BMI, presence or absence of breast cancer and its clinical-pathological charac...

The acylated form of ghrelin (GRLN) was discovered as the natural ligand of the GHS-R1a. GRLN is acylated by a specific octanoyl-transferase (GOAT) and is predominantly produced by the stomach, although expressed by many other endocrine and non-endocrine, peripheral and central tissues. Also GHS-R1is widely expressed by several central and peripheral tissues. Acylated GRLN displays strong GH-releasing activity but is not specific for GH exhibiting other neuroendocrine actions ...

Objective: This study aims to investigate whether DHEAS (Dehydroepiandrostenedione sulfate) inhibit the growth of leiomyoma.Method: Total 131 patients were recruited according to the leiomyoma size by transvaginal ultrasonography. Excluding twenties and over fifties, 88 patients were analyzed. The leiomyoma group was classified into three groups, such as mild, moderate and severe. The mild group was defined as the presence of at least one or two leiomyom...

Aim: The present study aimed to investigate the relationship of visceral fat accumulation with the existence of the carotid plaque in ischemic stroke patients.Materials and methods: Seventy patients (37 male, 33 female) with acute ischemic stroke were enrolled in the study. The carotid IMT and the existence of carotid plaque of the patients were evaluated by high resolution ultrasonography with a 7.5 MHz linear superficial array probe in B-mode. The abdo...