Endocrine Abstracts

Introduction: An increased Body Mass Index (BMI) has been associated with higher prevalence of many cancers, including differentiated thyroid cancer. However, no data have been reported about potential impact of BMI on aggressiveness of presentation and clinical outcome of medullary thyroid cancer (MTC).Aim: To evaluate the potential influence of BMI on clinical presentation and outcome of MTC.Methods: We reviewed anthropometric an...

Cushing’s disease tumours bear activating mutations in the ubiquitin-specific-protease 8 gene (USP8) gene in 40-60% of cases. We have previously observed that patients with USP8 mutant tumours have smaller tumour size and show a better response to high dose (8mg) dexamethasone stimulation test compared to those with wild type USP8 (1). The aim of this study was to define the role of USP8 on glucocorticoid receptor (GR) in corticotroph tumour cells. We did experim...

Introduction: 80–90% of insulinomas are smaller than 2 cm, equally located in the head, body and tail of pancreas. Computer tomography (CT) is 75%, magnetic resonance imaging (MRI) is 55–90%, endoscopic ultrasonography (EUS) is 85–95% and selective arterial calcium stimulation test (SACST) is 95–100% sensitive in the diagnosis of insulinomas. Here, we presented two cases of insulinoma which could not be located by conventional methods and evaluated with SAC...

Steroid hormones and bile acids are potent regulators of metabolism. The enzyme 5β-reductase (AKR1D1) has a crucial role in bile acid synthesis and also generates 5β-reduced dihydrosteroid metabolites, regulating intra-cellular steroid availability though the clearance of cortisol, testosterone, androstenedione, and progesterone. As AKR1D1 sits at the interface of bile acid synthesis and steroid metabolism, we have hypothesised that it plays a key role in metabolic h...

Objective: to evaluate the effects of metformin use on weight loss, improvement of ovarian and thyroid function in obese women with polycystic ovarian syndrome.Material and Methods: 30 obese (BMI 30–34.99 kg/m2) hypothyroid (TSH 6–10 mIU/ml) women of age 25–35 years old were included. The patients received appropriate levothyroxine treatment according to TSH levels and body weight. A number of 15 patients added metformin gradual...

Background: Metabolic complications (obesity, lipid abnormalities, and insulin resistance) are prevalent in acute lymphoblastic leukemia (ALL) survivors treated with cranial radiotherapy (CRT). The hypothalamus (HT) is a complex area involved in endocrine function and metabolic control. In ALL survivors, assessment of the volume of the HT in relation to metabolic parameters including ghrelin, a peptide stimulating food intake, has not been performed previously.<p class="ab...

Advances in genetic approaches to bone physiology have expanded our understanding of the mechanisms by which bone and energy homeostasis interact. PHOSPHO1, a bone specific phosphatase is essential for the initiation of bone mineralisation. Here we now show that Phospho1 ablation confers a remarkable protection against obesity and diabetes in mice. To understand the mechanism whereby Phospho1 impacts metabolism, microarray analysis of osteoblasts, the primary...

Introduction: Generously supported by IPSEN)-->Active acromegaly is reported to be associated with considerable body composition changes, with significant lean body mass changes found only in men.Patients and methods: In patients with active acromegaly (n=40) 24 females and 16 males, 48.9±6.4 years old, with BMI of 28.04±1.27 kg/m2, diagnosed 4.15±1.09 years ago, body composit...

Introduction: Multi Nodular Goitre(MNG) has a slow, progressive growth. An apparently asymptomatic MNG can already have caused retrosternal upper airway obstruction. Yet MNG can also cause compressive manifestations without retrosternal extension. Timing of surgery can be critical for patients with a large goitre. The evidence is poor to guide management of large MNG with absolute indications for surgery. The aim of this uni-centre study is to analyze patients with large MNG a...

Background: It is a controversial issue whether the risk of cancer for a thyroid nodule is different in patients with Hashimoto’s thyroiditis (HT) and in patients without thyroid autoimmunity. Some studies have reported an increased risk of malignancy in thyroid nodules associated with HT while only limited data based on fine-needle aspiration cytology (FNAC) are available.Methods: Between May 2005 and April 2011, 3279 ultrasonography-guided FNACs w...