Endocrine Abstracts

Introduction: Acromegaly is a chronic disease that affects morphology and organ functions. These changes lead to clinically relevant comorbidities. Untreated acromegaly reduces life expectancy by 10 years, mostly due to cardiovascular events, malignancies and respiratory disorders. We present the results of a series of 109 acromegalic patients at a single institution.Methods: Lung function tests were performed under standardized conditions in patients wi...

Introduction: Total thyroidectomy (TT) is a safe and effective operation. The most frequent complication after TT is hypoparathyroidism. Surgical trauma, devasculisation of parathyroid glands and inadvertent parathyroidectomy have been identified as the main causes resulting in postoperative hypocalcaemia. The objectives of this study are to investigate the incidence of intrathyroid parathyroid glands (ITPGs) in a large cohort and to clarify their histological characteristics....

Introduction: Despite more than 60 years’ experience with radioactive iodine 131I (RAI) treatment of Graves’ disease (GD) about the most appropriate dosing regime is still controversial. The objective of our research was to analyse the outcome of RAI therapy in our cohort of patients.Methods: Retrospectively, we analysed 603 patients with GD (500 women and 103 men, mean age 51.5±12.7 years) treated with RAI. According to recomme...

Aim: Mean platelet volume (MPV) is considered a new indicator of atherosclerosis. Activated platelets and subclinical inflammation predispose to create for atherosclerotic heart disease. Larger platelets are metabolically more active than smaller ones and have more protrombotic potential. We have recently demonstrated that MPV levels in Hashimoto’s patients tend to be higher than healthy controls even if in euthyroid state. In present study we aimed to investigate a relat...

Study for morphological and hormonal changes in the parathyroid glands in 35 patients with primary hyperparathyroidism was carried out. Post-mortem material (five bodies) used to control. All patients had primary hyperparathyroidism and elevated levels of parathyroid hormone and ionized calcium in serum. Morphometric study evaluated the cellular structure (chief and oxyphil cells) and calculated the ratio of the basic elements of parathyroid cells (nucleus, cytoplasm) and stro...

Introduction: Apart from occurring sporadically, insulinoma within the framework of multiple endocrine neoplasia 1 (MEN-1) is well known. The rare presence of multifocal insulinomas has recently been assigned a separate entity (insulinomatosis). The difficulty of localising insulinomas may be improved by GLP1-receptor imaging.Case report A 48-year-old woman had been treated for suspected epileptic seizures for 2 years (lamotrigine). During another such e...

Introduction: Graves’ disease (GD) is associated with a number of cardiovascular complications, including rhythm disturbances, mitral valve prolapse, pulmonary hypertension and heart failure. Pericardial effusion in the context of GD has only been reported in a small number of cases.Case: A 59-year-old gentleman presented with a 3-day history of dyspnoea and pleuritic chest pain. He had a previous history of GD 8 months ago, pulmonary embolism (PE),...

Background and aim: Incidentally discovered adrenal masses (adrenal incidentalomas (AI)), generally 1 cm or more in diameter, are mostly benign and asymptomatic and are often considered as nonfunctional tumors. The aim of this study was to perform the imaging characteristics, endocrinologic screening and histologic diagnoses of adrenal incidentaloma cases encountered in our institute.Methods: This retrospective evaluation of patients with AI includes 543...

Background and aims: Maternal BMI and weight gain are associated with maternal and fetal complications in gestational diabetes (GD), but their relative contribution is not clearly defined. Our aim was to determine the influence of BMI and weight gain in the evolution of GD.Material and methods: Multicenter, retrospective study of women diagnosed with GD at the medical centers of the Portuguese Group for the Study of Diabetes and Pregnancy in 2011. We use...

Macroprolactinemia is reportedly 10–25% in patients with hyperprolactinemia (1). Prolactin plays a major role in breast development (2). Macromastia, gigantomastia, breast hypertrophy are used interchangeably (3). Most authors conclude that gigantomastia cannot be treated medically and only resolves with surgical manoeuvres (4). We report a case with gigantomastia diagnosed with macroprolactinemia and treated with cabergolin.Case: A 44-year-old woma...