Endocrine Abstracts

The incidence of Graves disease in different regions of Russia ranges from 20 to 50 cases per 100000 population.Purpose: To improve the results of surgical treatment of patients with Graves disease by identifying the optimum amount of remaining thyroid tissue and prediction of thyroidal status in the long term.Methods and design: The 138 patients with Graves disease operated over the past 10 years: 131 women (94.9%) and 7 men (5.1%...

Introduction: Radioiodine (RAI) is used as a definitive therapy of hyperthyroidism due to toxic adenoma (TA) as well as toxic multinodular goiter (TMG). Achievement of hypothyroidism or euthyroidism is defined as a successful therapy.Methods: The study was conducted in 666 patients – 484 with TA and 182 with TMG (85.58% of women), aged 56.19±13.88 years. We analyzed retrospectively hormonal and imaging findings (scintigraphy, ultrasonography), ...

A 9-year-old boy presented to his local hospital having had a respiratory arrest at home. He had a background of a chromosomal microdeletion, and there had been several days of cough and coryza. CPR was underway and upon arrival in A&E he was resuscitated and retrieved to PICU. The working diagnosis was lower respiratory tract infection.On day 4 of his PICU stay, with progressive signs on his chest X-ray, an ultrasound scan was performed. Th...

Hypogonadotrophic hypogonadism (HH) is the only form of infertility that is directly treatable with hormone replacement, either in the form of gonadotrophin injections, or pulsatile GnRH if the underlying defect is hypothalamic and pituitary function is intact. However, men with HH face a complex and confusing journey to access treatment: misinformed that they are irredeemably infertile, struggling to find a clinician with relevant experience and authorisation to prescribe gon...

Pancreatic neuroendocrine tumours (PNETs), although reported with increasing frequency through increased use of abdominal imaging, are rare and uncommon tumours (1 per 100,000 population) representing 1–2% of all pancreatic neoplasms. Preoperative diagnosis is important since a solitary small tumour without evidence of metastatic spread may be suitable for pancreatic preserving surgery such as enucleation or middle segment resection rather than more extensive resection. H...

The sonic hedgehog (shh) pathway is known to be essential for pituitary development but little is known of its role in adult pituitary. Patched1, encoded by the Patched1 (Ptch1) gene, is a receptor for shh expressed in all cell types of the anterior pituitary. Adult onset hypogonadotropic hypogonadism has been reported in a genetically engineered mouse line with deletion of Ptch1 using S100a4 promoter driven CRE recombinase expression which is restri...

Fifty-three year old male presented to gastroenterologist with retrosternal pain and dysphagia. On gastroscopy a 2 cm soft sub-pedunculated polypoid mass in the lower oesophagus was identified and on biopsy it was confirmed as adenocarcinoma. CT scan confirmed the finding but additionally identified 20mm right adrenal “incidentaloma” with mild calcification and reassuring imaging characteristics, further supported by a low uptake on 18-FDG PET-CT. He underwent Ivor L...

A 56 years old lady was referred to our endocrine service for further management of levothyroxine replacement. She was diagnosed with Graves’ disease 26 years ago and underwent thyroidectomy as definite treatment. Post-operatively, she was commenced on 100mcg of levothyroxine and continued to have regular follow up with her GP. It was noted that her levothyroxine dose had to be reduced to 50 mcg daily over a period of 10 years due to persistently suppressed TSH levels wit...

Engaging with the public is becoming a key part of any research career and enables us to share our passion for endocrine research with the world, show how charity and government funding for endocrinology leads to new treatments and encourages the next generation of endocrine researchers. Whilst as researchers we are used to presenting our research at conferences and networking with our peers, engaging with the public about our research can be a daunting prospect. This talk wil...

Importance: The major factor contributing to the high incidence of osteoporosis in older women is the reduction in estrogen synthesis. Isoflavones have a similar structure to 17-β estradiol and can act as selective estrogen receptor modulators.Objective: To determine the safety and effect of soy isoflavones on bone during early menopause.Design: Parallel, double blind, study.Setting: Secondary care resea...