Endocrine Abstracts

Objectives: Oxidative stress is of critical importance in the pathogenesis of endocrinopathies. Since cholesterol serves as a major source of steroid hormone synthesis we investigated the effect of hypochlorite-modified low density lipoprotein (LDL) on aldosterone and cortisol release from human adrenocortical NCI-H295R cells.Methods: Native LDL obtained from healthy volunteers was oxidized to varying degrees by sodium hypochlorite. The resulting modifie...

There is no ideal treatment for the simple goiter. The treatment options in NMG is: surgery, I131, L-thyroxine or continous monitoring without therapy.From 2000–2003 we evaluated 150 patients (120 women and 30 men) having their agings between 20 and 80 years with L-T4 treatment for nontoxic multinodular goiter. Duration of therapy was 3 years. The pacients was evaluated by clinical examination, level of TSH, free-T4,...

We have collected an extensive record of more than 8000 patients with a thyroid carcinoma over the years 1946–2005. In all cases, the diagnosis was done by the histology examination carried by a pathologist. Those records were classified by their dimension and the extent of the thyroid gland. This classification is used as a basis for the treatment decision. Tumors of the bigger size needs radiotherapy with I 131 whereas the smaller tumors are subject of observation and r...

This study investigated the action of ferulic acid (FA) on the regulation of insulin sensitivity in high-fat diet (HFD)-induced obese mice. The ICR mice were fed with HFD (45 kcal% lard fat) for 16 weeks. Over the last 8 weeks of HFD feeding, these obese mice were orally administered with FA at doses of 25 and 50 mg/kg/day. At the end of all treatments, the epididymal fat, pancreas and hypothalamus were removed for analysis of biochemical parameters and expression of proteins....

Introduction: The association between papillary thyroid carcinoma and thyroiditis was first reported in 1955 by Daily, in 2023 if this association is well established, it still continues to be talked about. Does cancer precede thyroiditis or does thyroiditis induce cancer and when the two combine does cancer have a better prognosis?Material and methods: We report a prospective study carried out in a hospital center in Algeria between 2020 and 2022 which ...

Background: Prevalence of neuroendocrine neoplasms is increasing and multidisciplinary approach is mandatory. This study aimed to assess the outcome of patients with gastroenteropancreatic neoplasms (GEP NEN) presenting in a tertiary endocrine center.Methods: Retrospective study on 36 patients (16 M/20 F) with pathology confirmed GEP NEN, aged 51.9 ± 12.7 years. Serum chromogranin A, serotonin, neuron-specific enolase...

Thyroid C-cells, as a second type of endocrine cell population within thyroid, produce and secrete peptide hormone calcitonin (CT). This hypocalcemic hormone acts as an inhibitor of bone resorption. The aging is a complex process that alters various cellular functions. Therefore, the aim of this study was to examine the aging-related changes in the structure and function of CT-producing thyroid C-cells in male Wistar rats, using histomorphometric, ultrastructural and biochemic...

Background and Aims: Numerous studies have suggested that metabolic syndrome (MetS) is related to adrenal incidentaloma (AI) in young adults. Limited data about MetS in geriatric patients diagnosed with AI are available, despite the high incidence of this adrenal disease in the elderly. This study aims to assess the prevalence of MetS and its associated factors in aged patients harboring AI.Patients and Method: We conducted a retrospective, comparative, ...

Introduction: Angiomyolipomas are rare mesenchymal tumours arising from the perivascular epithelioid cells. They are benign endocrinologically inactive tumours with a histological structure consisting of variable amounts of adipose, thick-walled blood vessels and smooth muscle cells. Commonly, angiomyolipomas occur in the kidney with few extra renal case reports in adrenals.Case Report: We report the case of a 76-year-old-man with personal history of hyp...

Background: Parathyroidectomy is the only definitive treatment for primary hyperparathyroidism (PHPT). Identifying parathyroid adenomas (PA) before surgery is essential to perform minimally invasive surgery and to achieve higher cure rates.Methods: Retrospective study of patients with PHTP who underwent 18F-Fluorocholine Positron Emission Tomography- Computed Tomography (18FCH-PET-CT) between 2019 and 2021 at our center due to non-localization of PA or d...