Endocrine Abstracts

Serum thyroglobulin (Tg) is a biomarker used to assess iodine nutrition status, but data in pregnant women are scarce.Objectives: To determine serum Tg concentration in Spanish healthy pregnant women, and to evaluate its relation with yoduria (UIC), thyroid volume, iodine intake and thyroid function throughout pregnancy.Methods: Longitudinal study in pregnant women with no history of thyroid disease, recruited in 2 obstetric center...

Objectives: The aim of this study was to analyze the prevalence of some polymorphisms of the CTR-AluI, VDR-FokI, Col1A1y ER-α genes, (involved in bone metabolism), in our population. And evaluate the association of these polymorphisms with bone mineral density and fracture.Design, Patients, and Setting: We performed an observational prospective study in pre- and postmenopausal ambulatory women (n=72 and n=152, respectively).<p ...

Hyperthyroidism during pregnancy is determined by decreased thyroid stimulating hormone (TSH), and high levels of thyroid hormones: thyroxine (T4), triiodothyronine (T3), being a complication in 1–2 women per 1,000 pregnancies, and occurs first as Graves’ disease in 0.1–1% of pregnancies. There are specific reference ranges of THS and free T4 for each population and each trimester. For the medical management in the first trimeste...

Case report: A 50-year-old man was referred by his family doctor to the emergency room in September 2020 for intermittent abdominal pain in the right upper quadrant for several months. He also mentioned weight loss and several episodes of fever with chills. The patient was an active smoker, consumed large amounts of alcohol, and had no known medical history, nor taking any medication. At physical examination, the patient appeared pale and cachectic, with tende...

The adrenal gland produces corticosteroids essential for hydromineral and metabolic homeostasis. It is organised, in mice, in two concentric layers. The zona glomerulosa (zG) and fasciculate (zF), renewed from progenitors located in the capsular periphery. Centripetal renewal and maintenance of cortical zonation are dependant of a balance between WNT/β-catenin and ACTH/PKA signalling pathways. They provide recruitment and consecutive differentiation of progenitors into zG...

Adrenocortical carcinoma (ACC) is an infrequent and aggressive cancer that originates from steroidogenic cells within the adrenal cortex. Half of patients present with metastatic spread at initial diagnosis, and to date, there is no curative therapy for advanced disease. Recent genomic analysis has established that the most aggressive subgroup of ACC patients have overlapping alterations in the WNT/B-catenin pathway and the p53/RB pathway. We therefore set out to develop a met...

Adrenocortical carcinoma (ACC) is a rare and aggressive cancer that originates from steroidogenic cells within the adrenal cortex. The most common alteration in ACC patients is inactivation of the transmembrane E3 ubiquitin-ligase Zinc and Ring Finger 3 (ZNRF3), which is responsible for inhibiting the canonical WNT/Beta-catenin pathway. Using Cre/loxP strategy, we showed that inactivation of Znrf3 in the adrenal cortex resulted in an initial hyperplasia by 6-weeks, af...

The lipodystrophic syndromes are a heterogeneous group of congenital or acquired disorders characterized by either complete or partial lack of adipose tissue with the apparent accumulation of fat in other regions of the body. Their prevalence is low and ranges from 1:200000/500000 and they usually suffer metabolic abnormalities associated with the abnormal distributition of fat such as severe insulin resistance with acantosis and diabetes, progressive liver disease along with ...

Background: Adrenocortical carcinoma (ACC) is an aggressive cancer originating from steroidogenic cells within the adrenal cortex. Unfortunately, half of patients present with metastatic spread upon initial diagnosis, and there is no curative therapy for advanced disease. Genomic analysis has identified that the most aggressive subgroup of ACC patients have overlapping alterations in the WNT/β-catenin pathway and the p53/RB signaling pathway.Objecti...

Background: Prostate cancer (PCa) is the fifth leading cause of cancer-related death worldwide. The main pharmacological strategy for this pathology is the blockade of the androgen receptor signalling pathway, commonly known as androgen-deprivation therapy. However, some of the patients does no longer respond to this hormonal therapy. Therefore, finding novel therapeutic strategies to tackle PCa, especially its most advanced phenotype [i.e., castration-resistant prostate cance...