Endocrine Abstracts

Introduction: Gestational diabetes mellitus (GDM) is the metabolic disorder most frequently associated with pregnancy, presenting important maternal and fetal implications. Strict glycemic control through lifestyle measures and/or pharmacotherapy is essential to achieve adequate obstetric-perinatal results. The objective of this study is to compare baseline characteristics and perinatal results in patients diagnosed with GDM after performing oral glucose tolerance test (OGTT) ...

Background: Malnutrition affects 30-50% of patients with hematological malignancies; it is due to the disease itself, the treatment-related catabolic process and chemo-or radio-therapy side effects (nausea, vomiting, diarrhea and mucositis). Patients with poor nutritional status have increased morbidity (treatment complications, infections, mucositis) and mortality.AimTo evaluate the nutritional status of all patients that underwent hematopoietic stem ce...

Introduction: Women with gestational diabetes mellitus (GDM) have an increased risk for developing glucose intolerance in postpartum. The aim of our study was to describe the general characteristics of pregnant women with GDM and to assess the prevalence of glucose intolerance in early postpartum by postpartum oral glucose tolerance test (ppOGTT).Methods: Retrospective study from January 2017 to December 2020 including patients with GDM followed at endoc...

Purpose: Although growing evidence supports the role of primary cilia (PC) in the regulation of cancer development, their possible role has not yet been studied in pituitary neuroendocrine tumours (PitNETs). The study of cilia could serve as a diagnostic tool providing new insights into the mechanisms of tumorigenesis and aggressiveness of PitNETs. Methods: A total of 86 patients with PitNETs (28 functioning and 58 non-functioning [NF-PitNETs]) and 12 co...

The pituitary gland is a critical endocrine organ regulating multiple essential physiological processes including growth, reproduction, metabolism and the stress response. Hormone-producing pituitary cell lineages are derived from a population of embryonic precursors expressing the transcription factor SOX2. These cells maintain multipotency into early postnatal life, acting as the resident population of pituitary stem cells (PSCs) and contributing to all the endocrine cell li...

Metabolic associated fatty liver disease (MAFLD) is rapidly becoming a major aetiology for the development of hepatocellular carcinoma (HCC, the most common liver cancer) in the context of chronic liver disease. Current therapeutical options for MAFLD (dietetic/lifestyle intervention and/or pharmacological approaches) are still insufficient and the cellular and molecular mechanisms underlying this disease are yet to be fully understood. Our group previously reported that the n...

Introduction: Zinc transporter 8 (ZnT8) autoimmunity has been established as one of the markers for the diagnosis of type 1 diabetes (T1D) along with glutamate decarboxylase (GAD) and tyrosine phosphatase IA-2 (IA-2) antibodies. The aim of this study is to understand the status of pancreatic autoimmunity in the diagnosis of T1D, with special attention to the usefulness of ZnT8. In addition, as a second objective, we study the proposal to perform the assessment of pancreatic au...

Introduction: In gender affirming therapy of the transgender male, increasing doses of testosterone are administered and as the androgen dose increases, various biochemical parameters such as haematocrit, creatinine and PSA increase. It is not known whether any parameters have advantages in monitoring this androgenisation. Our study evaluates the correlation between the increase in androstanediol glucuronide, testosterone, free testosterone and free androgen index (FAI) with t...

Introduction: Urine free cortisol measurements are routinely performed to evaluate hypercortisolism. Despite their analytical inaccuracy, immunoassay-based methods are frequently used. Advances in liquid chromatography high resolution mass spectrometry (LC-HRMS) facilitate the incorporation of powerful diagnostic tools into clinical laboratories with high analytical specificity that also allow simultaneous quantification of different metabolites and untargeted compound identif...

The mutations of succinate dehydrogenase subunits (SDHA, SDHB, SDHC, SDHD) are linked with a predisposition to develop pheochromocytoma and paraganglioma, often in diferent locations of the body. With greater acces to genetic tests, current estimations suggest that 40-50% of pheocromocytoma and paraganglioma cases are inherited and half of them are due to SDH mutations. These mutations can be associated with other tumours like renal carcinomas, gastrointestinal stroma tumours ...