Endocrine Abstracts

Low plasma sex hormone-binding globulin (SHBG) levels are present in fatty liver disease, which represent a spectrum of diseases ranging from hepatocellular steatosis through steatohepatitis to fibrosis and irreversible cirrhosis. We have previously determined that fat accumulation reduces SHBG production in different non-alcoholic fatty liver disease (NAFLD) mouse models and that SHBG plays an active role in the development of this disease. In the present work, we are interes...

Objectives: Eversense XL is a fully implantable sensor for continuous glucose monitoring (CGM) that lasts for up to 180 days. Our objective was to perform a survey on user acceptance and satisfaction among our type 1 diabetic patients who had been using the Eversense XL CGM for at least 3 months.Methods: A questionnaire was devised in which the patients were asked about their experience with the Eversense XL CGM, including:-Compari...

Objective: Cushing’s disease (CD) is the most common cause of hypercortisolism after iatrogenic origin, it represents approximately 70% of patients with endogenous Cushing’s syndrome (CS) and ectopic ACTH secretion (10%). CD is caused by a corticotropin-secreting pituitary neuroendocrine tumor (ACTH-secreting Pit-NETs), 95% of cases as a microadenoma. In ACTH-dependent CS, differential diagnosis between CD and ectopic CS must be established. 40% of CD cases, any tumo...

Acromegaly is a rare disease usually diagnosed late in disease evolution. It implies for skeletal changes of most flat bones including those of the skull. Consequently, a progressive facial disfiguration occurs at slow velocity of irreversible nature. Even after curation most of these changes stay for the whole life of the patient.Aim: to study the potential relationship between disfiguring facial modifications and psychosocial and Quality of Life (QoL) ...

Introduction: The Biomedical Engineering Group of the University of Seville, the Endocrinology and Nutrition Unit of the Virgen Macarena Hospital (ENU-VMH) and the company Igluco Tech are developing the GLUCUBE device, a new non-invasive sensor for blood glucose measurement.Objective: First validation of usability and accessibility of the device by patients in a controlled clinical environment.Material and Methods: General user-cen...

Introduction: Flash glucose monitoring expansion to an increasing number of patients with type 1 diabetes, coupled with its increased accuracy and ease of use, has increased available data on glycemic control in this population and allows detection of improvement areas in diabetes education and treatment.Objective: To analyze main parameters standardized by ATTD consensus (2019) in our population of patients with type 1 diabetes using flash glucose monit...

Introduction: Subclinical hypothyroidism (SCHT) in pregnancy has been associated with adverse obstetric and perinatal outcomes. However, few studies have investigated the evolution of postpartum thyroid function in women first diagnosed with SCHT in pregnancy (gestational SCHT).Objective: To determine the evolution of thyroid function (TF) and the clinical and biochemical factors related to the long-term persistence of hypothyroidism (HT) in women with g...

Introduction: Recurrences of differenciated thyroid carcinoma are occasionally hard to locate; rhTSH-stimulated FDG PET-CT may offer a higher sensitivity, particularly when thyroglobulin in high, but its utility has not been clearly established. Methods: Review of the patient’s clinical record Results: A 61 years old woman noticed a right anterior neck lump when she was 47; FNAC was suggestive of a solid papillary thyroid carc...

Introduction: Hormone-producing pituitary cell lineages derive from SOX2+ embryonic precursors. These cells maintain multipotency into early postnatal life, acting as the resident population of pituitary stem cells (PSCs) and contributing extensively to all the endocrine cell lineages. Additionally, paracrine signalling from PSCs is important for cell proliferation of neighbouring progenitors (PMC7803373). It is not known if SOX2+ PSCs are involved in the regulation of additio...

Objective: The carbohydrate metabolism dysfunctions are common in critical ill patients with diabetes or stress hyperglycaemia and the correct management of them has an important prognostic value. Despite its limitations, capillary glucose (CG) was collected more than arterial glucose (gold standard) because of its good correlation. However, the usefulness of intermittent intersticial glucose monitoring (IGM) in keeping blood glucose within target range in critical ill patient...