Endocrine Abstracts

Introduction: Non-classical congenital adrenal hyperplasia (NCCAH) due to 21-hydroxylase deficiency is one of the most frequent autosomal recessive diseases. Genetic analysis performed for genetic counselling revealed a miscorrelation with the clinical diagnosis in several patients at our centre.Aim: Confirm the genetic diagnosis of NCCAH in women attended for this condition.Materials and methods: Consecutive patients attended at o...

Introduction: Cinacalcet is an oral calcimimetic indicated in treatment of primary hyperparathyroidism if patients do not accept surgery, do not carry out the surgical criteria, there is failure of previous surgery or serious comorbidity that makes surgery impossible.Methods: Descriptive study that included 20 patients with primary hyperparathyroidism who had complete at least 12 months of treatment with cinacalcet for different reasons (eight patients r...

Reduced expression or activity of the thyroid hormone receptors (TRs) are common events in cancer, suggesting that these receptors could act as tumor suppressors. We have previously shown that TRβ expression in SK-hep1 hepatocarcinoma cells (SK-TRβ cells), reduces tumor growth and strikingly inhibits invasion, extravasation, and metastasis formation in nude mice. These effects could be related to a decreased expression in these cells of prometastatic genes, such as C...

Case of 33 years old male patient with an unremarkable past medical history, who after a car accident, a cystic nodular right neck mass was incidentally found by MRI of cervical spine. Physical examination revealed a mildly tender right neck mass. He was clinically and biochemically euthyroid. Denied history of neck irradiation. No family history of thyroid disease or thyroid cancer. Excisional biopsy of right neck mass showed metastasic well differentiated papillary carcinoma...

In the normal adrenal gland, serotonin (5-HT) stimulates cortisol secretion through activation of 5-HT4 receptors whereas, in some macronodular adrenal hyperplasia tissues, the corticotropic effect of 5-HT is mediated by ectopic 5-HT7 receptors. The aim of the present study was to investigate the role of 5-HT in the control of cortisol secretion in PPNAD tissues from 12 patients by using molecular, immunohistochemical and pharmacological approaches. RT-PCR studies revealed ove...

Introduction: Cinacalcet is an oral calcimimetic indicated in treatment of primary hyperparathyroidism if patients do not accept surgery, do not carry out the surgical criteria, there is failure of previous surgery or serious comorbidity that makes surgery impossible.Methods: Descriptive study that included 34 patients with primary hyperparathyroidism treated with cinacalcet. We recorded clinical and biochemical data before and after 6 months of treateme...

Somatostatin (SST), Cortistatin (CORT), ghrelin, and their corresponding receptors (ssts and GHS-R) are closely interrelated systems involved in the regulation of essential hormones for metabolic homeostasis, like insulin, whose release is inhibited by SST/CORT and stimulated by ghrelin. To investigate the underlying mechanisms of this insulin regulation, we analyzed the expression of such systems at pancreatic level in wild type (WT) and CORT knock-out mice (CORT-KO) under bo...

Adipocytes are cells highly specialized in storing excess energy as neutral lipids in lipid droplets (LDs). These organelles act not only as mere fat reservoirs, but also as active modulators of lipid storage and mobilization in response to hormonal signals. This role is accomplished through a plethora of proteins associated with the LD surface that spatially and temporally coordinate lipid metabolism and traffic on demand. Recently, we have shown that the LD-associated protei...

Adipose tissue is a highly active metabolic organ which, together with its role as an energy storage depot, produces a wide variety of bioactive molecules (i.e. adipokines) with important roles in the regulation of energy metabolism and homeostasis, immunity and inflammation. Alterations in lipid metabolism and/or in adipokine production associated to the excess of adipose tissue that defines obesity or to adipose tissue deficiency, as occurs in lipodystrophy, are linked to in...

Background and aims: Use of potassium iodide (PI) supplements during gestation in mild to moderate iodine deficiency areas remains a controversial issue.Objective: Comparing the pharmacological effect of iodized salt versus iodide potassium supplements on the maternal thyroid function and neurodevelopment (Bayley Scales) of the progeny.Methods: One hundred and thirty one pregnant women were included from the first trimester (below ...