Endocrine Abstracts

Objetive: The aim of our study is to asses the validity of ultrasound patterns proposed by the ATA and malignancy risk in the cytological diagnosis classified by the Bethesda System.Methods: Prospective study including all thyroid nodules (with no previous cytological results), assessed in our center from July/2016 to June/2017. We classified nodules in ATA sonographic risk patterns and follow-up its fine needle aspiration (FNA) recommendations. The stat...

Sex hormone-binding globulin levels are low in adult subjects with obesity when compared to normal-weight individuals. Obesity is associated with higher tumor necrosis factor alpha (TNFα) plasma levels and lower adiponectin levels. Moreover, we have recently elucidated the molecular mechanisms by which TNFα and adiponectin regulate hepatic SHBG production. The main objective of this study was to assess if the adult associations between TNFα, Adiponectin and SHBG...

IntroductionDyslipidemia is a major cardiovascular risk factor, being its detection and control essential due to risk of serious complications. Numerous trials have demonstrated its relationship with T2D, but it has not been so well studied in T1D.ObjectiveTo obtain information about relationship between dyslipidemia and T1D and analyze its prevalence and control in a sample of patients.<p class="abstext"...

Sex hormone-binding globulin (SHBG) is a circulating plasma glycoprotein produced by the liver, which in the blood binds estrogens and androgens with high affinity and regulates its bioavailability. Low plasma SHBG levels are associated with obesity, metabolic syndrome and non-alcoholic fatty liver disease. Importantly, epidemiological studies have demonstrated that low plasma SHBG levels is a risk factor for developing type 2 diabetes and cardiovascular disease. In the last y...

Background: Despite a high relapse rate, antithyroid drugs (ATDs) remain the first-line therapy of Graves’ disease (GD). Long-term follow-up studies of GD in Spain are scarce. Our aims were to identify clinical differences between patients who relapsed vs those who attained remission and to describe the relapse rate of GD after ATD withdrawal.Methods: We analyzed patients with the first episode of GD who were treated with ATDs during 2010 - 2020, in...

Craniopharyngiomas (CPs) are a relatively benign subtype of epithelial tumors that typically originate from the sellar and suprasellar regions of the brain. These endocrine tumors are classified as adamantinomatous (ACP) or papillary (PCP) based on their histological characteristics. Unfortunately, the diagnosis of CPs is frequently made at an advanced stage of tumor development, and therefore relevant associated comorbidities are often present. The first-line treatment is typ...

Introduction: In May 2020, during the COVID-19 pandemic, the Spanish Group of Diabetes and Pregnancy published a consensus document establishing the alternative diagnostic criteria for gestational diabetes mellitus (GDM) in case of impossibility to perform the two-step traditional approach due to the COVID-19 sanitary emergency. This study aims to compare different characteristics of pregnant women who tested positive in the O’Sullivan test in the same pregnancy trimester...

Corticotrope cells give arise to utmost aggressive and to very rare pituitary neoplasias, including pituitary carcinomas, Crooke’s cell adenomas (CCA), clinically non-functioning silent corticotrope adenomas (SCA) and the Cushing-provoking pituitary adenomas (CD). The molecular etiopathogenesis of these tumors are still poorly understood. Therefore, we carried out whole exome sequencing to better understand the full genomic landscape single nucleotide variants and copy nu...

Introduction: Because of the increase of brain image explorations, the prevalence of pituitary tumours has increased a lot. Although most of them have an indolent behaviour, some behave aggressively, demanding a lot of resources for their management. Therefore, it is very important to identify them as soon as possible. The recent WHO 2017 classification of pituitary tumours gives insights into improving their identification using the immunostaining (IS) of transcription factor...

Introduction: Overt thyroid dysfunction in pregnancy without an early diagnosis and treatment may lead to an increased risk of adverse maternal and fetal outcomes. In this study, our goal was to assess the results of the development of a laboratory alerting system for the diagnosis of thyroid dysfunction in the first trimester of pregnancy. Material and methods: Observational retrospective study evaluating clinical and biochemical data from pregnant wome...