Endocrine Abstracts

Background: Struma ovarii, defined as containing 50% or more thyroid tissue is rare and accounts for 1% of ovarian tumours. Presentation is non-specific, relating to mass effect. Although the tumour predominantly consists of thyroidal tissue, features of hyperthyroidism occur in <5% of cases. Majority are benign, histological features of thyroid cancer are found in about 5–10%. Seventy per cent of these are papillary thyroid cancer (PTC). We present a case of struma o...

Introduction: Thyrotoxicosis is a common endocrine disorder; variable degree of hepatic dysfunction is often seen with thyrotoxicosis. Severe liver dysfunction associated with thyrotoxicosis occurs rarely. The prevalence of liver abnormality with thyrotoxicosis is reported to be ~ 15–30%. The mechanism of liver abnormality is not well understood; direct thyroid hormone mediated hepatocyte injury has been raised as a possible mechanism. We conducted a retrospective review ...

Introduction: T2DM prevalence in Belarus is 3.489.5 per 100 thousand people, annual growth rate is 5–6%. STEPS study: in 2016–2017 the following risk factors prevailed: overweight and obesity (61.2%), dyslipidemia (36%), hypertension (50%); inactive lifestyle (78.2%). The study aim was to assess risk factors for metabolic disorders in a young healthy population. Objective. 253 people were examined: 22.1% of men and 77.9% of women under 40. Methods: We performed ant...

Purpose: To study the state of the microvasculature and tissue metabolism (according to the dynamics of the FAD and NADH coenzymes) using laser Doppler fluometry (LDF) and laser fluorescence spectroscopy (LFS) in patients with diabetes mellitus.Materials and methods: To implement the combined use of LDF and LFS methods, the Laser Diagnostic Device LAZMA ST was used (registration certificate of Roszdravnadzor No. RZN 2017/5844 of June 08, 2017).<p cla...

Adrenal cortical carcinoma is a rare disease with an incidence of 1–2/million per year. Diagnosis is related to autonomy of adrenal steroid synthesis, tumour size above 6 cm, local invasion and tendency to recurrence. Treatment consists in adrenal surgery, non-specific chemotherapy and radiotherapy, and, more specific-Mitotane (Lysodren).Pathology diagnosis is based on capsular and vascular invasion, histological changes suggestive for malignancy an...

Background: Intravenous bisphosphonates treatment brings real benefits to patients with bone metastases. Unfortunately, this treatment sometimes has a difficult to treat complication, often disabling for the patients – the osteonecrosis of the jaws. A new approach in the management of this complication is the use of platelet rich plasma (PRP).Patients and methods: Five patients aged between 62 and 72 years old (three men and two women) were included...

Objective: To outline the risk factors, the epidemiological profile, and the classification of diabetes type two foot ulcer.Methods: A prospective observational study, including all the people that sought out in a consecutive way, a tertiary diabetic foot service, from February 2002 until September 2012. At admission, the patients were examined and had their ulcers evaluated by only one observer, in accordance with the University of Texas classification....

Pituitary sarcoidosis is a rare form of neurosarcoid, commonly associated with multisystemic sarcoidosis. The most common intracranial site of sarcoidosis leading to endocrine involvement is the hypothalamus and the pituitary gland. The prevalence of hypothalamic–pituitary involvement in multisystemic sarcoiosis is reported to be around 5%.Granulomatous infiltration of the hypothalamus and the pituitary gland always results in endocrine disorder, GH...

Objective: Exogenous and endogenous opioids affect the hypothalamic–pituitary–gonadal axis through binding to receptors centrally and by peripheral inhibition of testosterone synthesis, thereby altering the release of hormones. Approximately 12% of patients with persistent non-cancer pain use strong opioid analgesics in the UK, but the action on endocrine function may not be recognised. The aim of this study is to establish the incidence of gonadotrophin and other en...

Background: Normal pregnancy is a state of physiological oxidative stress (OS) with oxidants facilitating the implantation of the embryo and optimal decidualisation but counterbalanced by antioxidants. Pro-oxidant processes exceeding the anti-oxidants capacity result in imbalanced OS, which has been associated with the ‘’big four’’ obstetric complications: pre-term birth, intra-uterine growth retardation, pre-eclampsia and diabetes gravidarum. Important OS ...