Endocrine Abstracts

Introduction: Extrathyroidal unique laterocervical masses are infrequent, and their etiological diagnosis is difficult. Since clinical and imagistic features cannot distinguish between different ethiologies, morphological data are mandatory in order to establish a precise therapeutic strategy. Therefore the initial treatment is surgery, followed by an adequate therapeutical scheme. We would like to report our experience treating this pathology.Patients a...

Temozolomide, an alkylating agent used in malignant gliomas, has been recently used too in the treatment of aggressive pituitary tumors. To date, two cases of Nelson’s syndrome has successfully treated with 5 days of 28-day cycle, but the follow-up has been shorter than 12 months. We reported the third patient with Nelson’s syndrome treated with temozolomide, who after an initial goal response to three 300 mg 5 days of 28-day cycles shown a clinical and biochemical (...

The importance of cell cycle regulation in pituitary biology has been suggested from the fact that many gene-targeted mouse models of cell cycle mutations develop diverse pituitary pathologies. The retinoblastoma protein (pRb)/cyclin-dependent kinase 4 (Cdk4) pathway, one of the major mitogen-sensor routes in the cell, seems to be critical in the control of pituitary cell proliferation. Both inactivation of pRb or hyperactivation of Cdk4 result in pituitary hyperplasias or tum...

Papillary thyroid carcinoma is a slow growing tumor and is reputed to have an excellent prognosis. In 10–20% of cases, the presence of lymph node metastases led to diagnosis.Objective: To present a patient with enlarged lateral cervical masses, present for 10 years, that proved to be lymph nodes with metastatic thyroid papillary carcinoma.Case report: We report a case of an 26-year-old female patient with 10 years evolution of...

Aim: To study prevalence of foot complications in patients on dialysis therapy and evaluate the role the haemodynamic changes during dialysis procedure in development of foot problems.Methods: 109 dialysis patients, mean age 49 years. 60 of them had diabetes mellitus (DM): 29 on haemodialysis (HD), 31 on peritoneal dialysis (PD). Non-diabetic patients (NDM): 24 HD, 25 PD.Vascular status: doppler, photoplethysmography. Polyneuropath...

The usefulness of bone mineral density (BMD) and bone turnover markers measurements to assess the renal osteodystrophy in patients with chronic kidney disease, stage 5 (CKD5) are not well determined.The aim was to analyze BMD, serum levels of parathyroid hormone (PTH) and bone turnover markers in dialysis patients. We examined 45 patients (20 f,25 m; age 45.1±10.8 yrs; age at dialysis onset 40.3±12.3 yrs; dialysis duration 5.0±4.0 yrs). BM...

Background and Aim: One of the greatest problem in pregnancy, complicated by diabetes is screening and appropriate care for women, whose diabetes is manifested during pregnancy. The study is aimed at gathering epidemiological data on gestational diabetes mellitus (GDM) and evaluating the of appropriate therapy in this condition.Materials and Methods: Screening for GDM was carried out in – 692 pregnant women. GDM was observed in 3.3% (22 women) and i...

Most authorities recognise adult growth hormone deficiency (AGHD) as a distinct endocrine disorder, although determining an appropriate strategy for optimising replacement remains controversial.We reviewed the outcome of a cohort of patients treated with a fixed graded initiation phase followed by an individualised titration phase. Patients were initiated on a starting dose of 0.3 mg recombinant human growth hormone (rhGH) for one month, with increases t...

Aims: To evaluate the clinical features and long-term therapeutic outcome of giant prolactinoma (gPRLoma) in men and to compare them with those of a group of male patients with non-gPRL macroprolactinomas (non-gPRLomas).Patients and methods: A retrospective and multicenter study of gPRLomas in men diagnosed in a 20-year period was performed. Clinical data and treatment outcome were registered. The diagnosis of gPRLoma was established when the maximal tum...

Inactivating mutations in the thyroid hormones (TH) transporter monocarboxylate transporter 8 (MCT8) lead to the X-linked rare disease named MCT8 deficiency or Allan-Herndon-Dudley Syndrome (AHDS). AHDS pathophysiology is characterized by peripheral hyperthyroidism and cerebral hypothyroidism, which results in severe neurological impairments. Although AHDS leads to a spectrum of severe endocrine and neurological alterations, treatment options for MCT8-deficient patients are li...