Endocrine Abstracts

Introduction: Graves’ orbitopathy is usually associated with Graves’ Disease, which is typically characterized by hyperthyroidism and goiter. However, in rare situations, Graves’ disease can also present with hypothyroidism and orbitopathy.Case report: Male, 38 years old, followed by his ophthalmologist for thyroid orbitopathy (exophthalmos right>left and conjunctival hyperaemia since 1 year ago) associated with asthenia, tiredness and...

Seventy percent of women bearing PCOS are obese; adiponectin and TNFα, as obesity markers, have a dual role in the sensitivity and action of insulin. Adiponectin (insulin sensitising) decreases, whereas, TNFα, IL6 (negative regulators of insulin pathway) increases in obese-women. Moreover, TNFα decreases the transcript and protein levels of adiponectin. These changes could affect the normal energetic status in endometrium, tissue that exhibits abnormal insulin s...

Introduction: Diabetic nephropathy (DN) is one of the most serious chronic complications of diabetes mellitus characterized by persistent albuminuria, raised arterial blood pressure, a lowered glomerular filtration rate, and high-risk of cardiovascular morbidity and mortality. The vascular genes (Angiotensin-converting enzyme) ACE, and (aldosterone synthase) CYP11B2 are involved in alterations in vascular endothelium, and are suggested to play a role in the susceptibi...

Background: Replicating the physiological cortisol secretion is key in treatment of glucocorticoid insufficient individuals. A sub-optimal replication may explain the impaired quality of life experienced by these individuals. The study investigates fatigue measured by ecological momentary assessments in patients treated with conventional hydrocortisone compared with a once-daily dual-release formula of hydrocortisone (Plenadren) that follows the cortisol physiology more closel...

Insulin resistance is a feature of polycystic ovary syndrome (PCOS) and is related to mitochondrial and endothelial function.We tested whether hyperandrogenic insulin-resistant women with PCOS, who have an increased risk of vascular disease, display impaired leukocyte-endothelium interactions, and mitochondrial dysfunction. This was a prospective controlled study conducted in an academic medical center.The study population consisted of 43 lean reproducti...

Circulating C3 levels are elevated in obese patients, but how this factor is affected after weight loss through diet is a question that is yet unanswered. Therefore, the aim of this study was to evaluate the effects of weight loss on lipid and hydrocarbonated metabolism parameters and on the levels of C3 and C4 components of complement in obese patients. This is a longitudinal intervention study based on a 6 week very low calorie diet (VLCD), a liquid formula of 603 kcal/day. ...

Diabetes is associated with oxidative stress. This study evaluated the rates of oxidative stress and mitochondrial impairment in type 2 diabetes patients. The study population consisted of 182 diabetic patients and 50 body-composition- and age-matched controls. We assessed anthropometric and metabolic parameters and mitochondrial function by evaluating mitochondrial oxygen (O2) consumption, reactive oxygen species (ROS) production, glutathione (GSH) levels, GSH/GSSG ratio, mit...

In pheochromocytoma, intense lypolitic activity may lead to altered lipid profile, which can reverse after tumour removal.Aim: In this study, we evaluated before and at 3 months after surgery for a cathecholamine secreting tumour, a group of 19 patients diagnosed with pheochromocytoma (17) or paraganglioma (2).Patients and methods: 13 women and 6 men, aged 53.68±12.75 years (36–75), presented with a clinical picture of pa...

Case 1: Thirty-eight year woman consulted to gynecologist for oligomenorrhea in the last 4 years; PRL 51 μg/l and TSH 8.4 mU/l were discovered, initiating treatment with levotiroxine (f-T4). She got pregnant, persisting elevated levels of TSH and increasing f-T4, with normal campimetry. With the diagnostic of hyperthyroidism due to inadequate TSH secretion, treatment with PTU was initiated. After normal delivery, MRI showed a 22 mm. hypophisary macroadenoma and a transesp...

Insulin continuous s.c. infusion (ICSI) is an alternative therapy in selected diabetic patients when a good metabolic control is not achieved with multiple insulin doses (MID). We report the follow-up of patients with ICSI at least during 1 year in our centre.Patients and methods: Twenty-five patients (16 females, 9 males), with median age 38.4±12.5 years and diabetes evolution mean time 16.8±7.8 years, were changed from MID to ICSI due to defi...