Endocrine Abstracts

Background: Acromegaly is characterized by hormonal excess of GH and IGF-1, however many patients suffer from hypopituitarism as a result from either disease or treatment. Quality of Life (QoL) is known to be reduced both in acromegaly, with mixed results on the role of biochemical control herein, and hypopituitarism. Studies report the level of surgery-induced hypopituitarism after acromegaly at 12.79% (CI 9.88–16.00%). Treatment of acromegaly aimed at normalization of h...

Anacardium occidentale is a multi-purpose tree of the anacardae family with great economic and medicinal value. The leaf of the tree has been reported to possess hypoglycaemic and anti-diabetic properties. However, literature is devoid of any molecular basis for the potent effects observed. This study evaluated the molecular mechanisms underlying the efficacy and safety of the leaves by investigating glucagon-like peptide 1, insulin and kidney injury molecule genes us...

The dampening of hypothalamic–pituitary–adrenal (HPA) axis responses to a repeated stress is termed HPA habituation. We investigated here the effects of two commonly used repeated restraint stress paradigms, in which rats are exposed either to 10 episodes of 0.5 h restraint or 5 episodes of 3 h restraint. We compared ACTH, corticosterone, and testosterone responses, as well as corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA levels within bra...

Although it is becoming increasingly clear that testosterone exerts an inhibitory influence on stress-induced adrenocorticotropin (ACTH) and corticosterone release, where and how this occurs in the brain remains poorly understood. We previously determined that androgen receptors are not distributed within anterior pituitary communicating neurons of the paraventricular nucleus (PVN) of the hypothalamus (Bingham et al. J Comp Neurol 2006). However, they are contained with...

Isochromosome Mosaic Turner Syndrome (IMTS) is a variant of Turner Syndrome (TS) characterized by cytogenetic profile of 1 or more additional cell lineages aside from 45,X, and the presence of a structurally abnormal X chromosome consisting of either two short or two long arms. IMTS is rare, with only 8–9% prevalence among women with TS based on international studies, and 15% of all TS in the Philippines. A 20 year old female came in due to amenorrhea and alopecia. Physic...

Case history: We report a 38 year-old Caucasian woman with classical salt wasting congenital adrenal hyperplasia (CAH) who increasingly omitted medication in adolescence and eventually spent over 10 years without any adrenal replacement therapy or adrenal crises and became lost to follow up. When seen, she complained of increasing abdominal girth, fatigue, hirsutism, had type 2 diabetes, had never had a romantic/sexual relationship and was amenorrhoeic. Examination revealed ab...

Introduction: Cardiac paragangliomas are rare endocrine neoplasms. Surgical resection is first line treatment. Here, we describe a case of cardiac paraganglioma where surgical resection was aborted due to involvement of important cardiac structures. Systemic therapy was instead pursued with tyrosine kinase inhibitor cabozantinib.Case: A 64-year-old man with a past medical history significant for tobacco use and poorly controlled type 2 diabetes mellitus ...

Introduction: Obesity is nowadays one of the most important challenges in public health and, therefore, the investigation of their causes is most relevant. Among the various behavioral roots of obesity, the emotional over ingestion determined by emotional factors, i.e. emotional eating (EE), is one of them.Objectives: To study how emotions contribute to obesity in woman.Methods: We gathered a convenience sample 220 woman in the hos...

Background: Vitamin B12 (B12) is an essential micronutrient required for optimal hematopoietic, neurologic and other several metabolic reactions. Longitudinal studies and animal models showed that low maternal vitamin B12 deficiency is associated with the maternal obesity, development of insulin resistance and metabolic syndrome phenotype. Although the mechanisms underpinning metabolic disorders remain poorly defined, it has become increasingly cle...

Background: Vitamin B12 (B12) is an essential micronutrient required for optimal hematopoietic, neurologic and other several metabolic reactions. Longitudinal studies and animal models showed that low maternal vitamin B12 deficiency is associated with the maternal obesity, development of insulin resistance and metabolic syndrome phenotype. Although the mechanisms underpinning metabolic disorders remain poorly defined, it has become increasingly cle...