Endocrine Abstracts

Thyroid hormones (THs) play a crucial role orchestrating neurodevelopment, but also regulate adult brain function. Recently, the potent effects that THs exert in adult neurogenic niches have started to be uncovered in rodents. These include an important role in the modulation of progenitor generation, especially controlling whether a neural stem cell (NSC) determines to become a neuronal or an oligodendroglial progenitor in the adult subventricular zone (SVZ), the largest NSC ...

Introduction: Non-alcoholic fatty-liver disease and T2DM remain a global burden. Metformin is the first-line drug for T2DM that decreases glucose and lipid levels. However, prolonged metformin treatment decreases vitamin B12(B12), whereas low B12 is associated with obesity and dyslipidaemia. Clinical studies showed that metformin treatment increases circulating adiponectin and adiponectin improves NAFLD. Others suggested that metformin has no effect on intrahepatic triglycerid...

To analyze the data of relatives of first-degree patients operated on for medullary thyroid cancer (MTC), we analyzed the anamnestic data of the database of patients with MTC, formed on the basis of the cancer registry of the Republic of Belarus and medical records of the Republican Thyroid Tumor Center. Further examination of relatives is also performed on the basis of the Republican Center for Thyroid Tumors.The aim: of the study was to create a databa...

Assessment of basal calcitonin as the main marker of medullary thyroid cancer (MTC) was introduced into routine practice in the Republic of Belarus more than 10 years ago. A number of laboratory and clinical factors can influence the result of this parameter determination. Equally important is the gender, age, weight, the deviation of the serum calcium level, certain medications.The aim: Of the study was to develop and implement of stimulated calcitonin ...

Anacardium occidentale (cashew tree) belongs to the Anacardiaceae family and has been well used in folklore medicine for the treatment of various ailments such as gastrointestinal disorders, hypertension and diabetes. Literature is replete with reported anti-diabetic actions of cashew leaf. The molecular mechanism of the hypoglycemic activity of A. occidentale was investigated in this study. Insulin, Glucagon like peptide-1 (GLP-1), dipeptidyl peptidase-4 (DP...

Adrenocortical cancer is a rare, aggressive disease, requiring a fast and multidisciplinary approach. The genetics is heterogeneous so is also the clinical course. In the last 10 years, we have diagnosed and treated a number of 20 cases, aged at diagnosis between (34–74 years) (mean 55.9±12.87), followed up between (2–77 months) (mean 25.75±23.58). The maximal diameter of the tumor was (5.5–25) (mean 10.95±5.43). The secretion profile was Cushing ...

Introduction: Fragility fractures are increasingly recognized as a complication of diabetes mellitus (DM). Disease duration, poor glycemiccontrol, diabetes complication, and glycemic variability may be associated with increased risk.Aim: To investigate the association between glycemic control and hip fracture (HF) risk in a cohort of diabetic patients.Methods: This retrospective cohort study included all patients 50 years and older...

Background: First-line therapy of ACTH-independent Cushing’s Syndrome (CS) is the resection of the underlying tumor in all cases. After surgical cure of CS, most patients develop transient secondary adrenal insufficiency with a variable time of recovery. Adrenal function testing can identify patients who may require glucocorticoid replacement.Methods: We reviewed 61 patients diagnosed with ACTH-independent CS excluding 6 with adrenocortical carcinom...

The incidence of Graves disease in different regions of Russia ranges from 20 to 50 cases per 100000 population.Purpose: To improve the results of surgical treatment of patients with Graves disease by identifying the optimum amount of remaining thyroid tissue and prediction of thyroidal status in the long term.Methods and design: The 138 patients with Graves disease operated over the past 10 years: 131 women (94.9%) and 7 men (5.1%...

Aim: Chromolaena odorata and Tithonia diversifolia have been combined as folkloric treatment for pediatric anemia. However, the underlying molecular mechanism of this pharmacology has not been established. This study sought to establish the effects of these plants on erythropoietin (kidney), and erythropoietin receptor (bone marrow) expression and to monitor cyclin-dependent kinase inhibitors, and FasL/FAS signaling mechanism therefrom....