Endocrine Abstracts

Introduction: Sex steroid hormones play a key role in bone health, however medical therapies for gender dysphoria lead to hormonal changes.Purpose: Understanding the change in bone mass and body composition is extremely important, because this treatment will be carried out over a long period of timeMethods: In a prospective study, we included 19 transgender men (female-to-male trans persons) before treatment and after 1 year of tre...

Introduction: Flash glucose monitoring expansion to an increasing number of patients with type 1 diabetes, coupled with its increased accuracy and ease of use, has increased available data on glycemic control in this population and allows detection of improvement areas in diabetes education and treatment.Objective: To analyze main parameters standardized by ATTD consensus (2019) in our population of patients with type 1 diabetes using flash glucose monit...

Background: Genomic damage plays an important role in the pathogenesis of Type 2 Diabetes Mellitus (T2DM) and its complications. This instability increases with impaired metabolic control, and is aggravated by the presence of advance glycation-end products (AGEs) causing more cell damage. The aim of this study was to analyse the presence of genomic instability in patients with T2DM and its association with the levels of AGEs, namely glycated h...

Background: Genomic damage plays an important role in the pathogenesis of Type 2 Diabetes Mellitus (T2DM) and its complications. This instability increases with impaired metabolic control, and is aggravated by the presence of advance glycation-end products (AGEs) causing more cell damage. The aim of this study was to analyse the presence of genomic instability in patients with T2DM and its association with the levels of AGEs, namely glycated h...

Objectives: To analyze the data of patients seen at the Diabetes and Pregnancy Unit, assessing the frequency of pregnancy planning and whether there are differences in the degree of metabolic control before and during pregnancy, as well as in perinatal outcomes with respect to those who do not plan. All women of childbearing age with Pregestational Diabetes Mellitus(PGDM) should receive preconception counseling to optimize glycemic control, since preconception control is assoc...

Introduction: Gastric NENs are increasingly being diagnosed at endoscopy. The majority of these are type 1 gastric NEN. However, around 10–20% can be type 3 or type 4 Gastric NENs.Methods: A retrospective review performed of 54 patients with gastric NENs referred to a tertiary centre during 2014 to 2019.Results: Of the 54 cases referred, 45 were type 1 gastric NENs and the 9 were type 3 Gastric NENs. Of the 45 type 1 gastric N...

Introduction: Hyperparathyroidism-Jaw Tumor (HPT-JT) syndrome is a rare genetic disorder bearing a germline and a somatic CDC73 mutation. The features of HPT-JT are clinically difficult to ascertain because the parathyroid disease, ossifying fibroma in the jaw and other abnormalities, often occurs asynchronously and may be diagnosed and treated separately. The association of jaw ossifying fibroma with primary hyperparathyroidism (PHPT) is typical of HPT-JT.<p class="abstex...

Retrospective study of patients with metastatic/progressive pheochromocytoma (PCC) and paraganglioma (PGL) treated with (131) I MIBG in our hospital during 2015–2018 period.Methods: There are no established criteria for establishing PCC/PGL as malignant apart from de presence of metastases at diagnosis. Radionuclide therapy (131) I-metaiodobenzylguanidine (MIBG) is frequently used in this patients when surgery is not possible. Indication of MIBG tre...

Introduction: Amiodarone is an antiarrhythmic iodine-rich drug, known to induce thyroid dysfunction both due to its high iodine content and through amiodarone-induced thyrotoxicosis (AIT), being this latter process classified into three different types. Type 1 is associated with increased thyroid hormone synthesis; type 2 is a destructive process with thyroid hormone release and type 3 is thought to be a mixture of the former two. Since treatment options are different, there h...

Differentiated thyroid carcinoma (DTC) is the most frequent endocrine neoplasm. Follicular thyroid carcinoma (FTC) is the second histological variant in frequency after papillary thyroid carcinoma (PTC). Cerebellar metastases from DTC are extremely rare, corresponding about 1% of all cerebellar metastases, and being the majority metastases from PTC. To the best of our knowledge there have been no reported cerebellar metastases from CFT so far. We present here the first clinica...