Endocrine Abstracts

Introduction: Hybrid closed loop (HCL) systems are made up of continuous glucose monitoring (CGM) sensor, an algorithm that receives the readings from the CGM and an insulin pump able to deliver variable insulin doses according to the information received from the other two parts. Predictive low-glucose suspend (PLGS) insulin pump is able to stop the administration of insulin before hypoglycemia occurs. These new technologies are meant to improve the quality of life and help t...

Background: Bioresorbable screws for surgical fracture treatment are of great interest for the orthopaedic community. Such implants are designed to provide stability and compression of the fracture and should dissolve after healing, thereby making removal of surgical material obsolete. Magnesium implants are a new material option. So far, long-term follow-up of fracture healing and material decay has not been studied in human. Here, we present the results of the 2.5 year follo...

Macrophages play essential roles in the immune defence and their hyperactivation has been implicated in epithelial damage in acute respiratory distress syndrome (ARDS), commonly observed in severe COVID-19 patients. In these cells, SARS-CoV-2 spike (S) protein triggers aberrant production of pro-inflammatory cytokines like interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), as well as reactive oxygen species (ROS) and matrix meta...

Background: Patients with type 1 diabetes have a significantly higher risk of coronary events, as well as diseases of the cardiovascular system.Purpose of the study – to show the relationship between metabolic, structural, and functional parameters of the cardiovascular system in young patients with DM1.Methods: The study included 60 patients without CVD: 40 patients with DM1 and 20 patients without DM1, the groups were comparable in age, sex, AMT, ...

Background: The recommended method of initial testing for MEN2A is either a single or multi-tiered analysis to detect RET mutations in exon 8, 10, 11, 13, 14, 15, and 16.The aim of the study was to determine the relationship between the aggressiveness of the clinical course of MTC and identified mutations.Materials and methods: The research is carried out of the program ‘To develop and implement effective technologies for the ...

Background: Neuroendocrine tumors present in the MEN-1 syndrome are usually located in pancreatic islets and more than 10% appear de novo, affecting any age group. The debut of a carcinoid tumor is rare, with a prevalence of 2% of bronchial carcinoid tumors. Materials and methods: We present the case of a 49-year-old woman referred from the Oncology clinic for the assessment of thyroid incidentalomas found in a follow-up CT scan of multifocal bronchial c...

Introduction: Publications suggesting that thyroid nodules might be associated with insulin resistance (IR) and metabolic syndrome are quite interesting. The aim of the work is to analyze the association between anthropometric indicators IR and insulin-like growth factor-1 (IGF-1) in patients with nodular goiter. Methods Examined 73 patients with euthyroid single-node (n=34) and multinodular goiter (n=39), age (51.0±10.6) years; determinin...

Background: Vitamin B12 (B12) deficiency results in disturbance of 1-carbon metabolites [methylmalonyl coenzyme A (MMA), homocysteine and S-adenosyl homocysteine (SAH), S-adenosyl methionine (SAM) and methionine] that collectively affect lipogenesis leading to risk of cardiovascular diseases. In clinical studies, B12 deficiency is associated with higher BMI and dyslipidaemia (high triglycerides and low HDL). The role of B12 in hepatic metabolism of...

Background: Vitamin B12 (B12) deficiency results in disturbance of 1-carbon metabolites [methylmalonyl coenzyme A (MMA), homocysteine and S-adenosyl homocysteine (SAH), S-adenosyl methionine (SAM) and methionine] that collectively affect lipogenesis leading to risk of cardiovascular diseases. In clinical studies, B12 deficiency is associated with higher BMI and dyslipidaemia (high triglycerides and low HDL). The role of B12 in hepatic metabolism of...

Background: Short Synacthen Test (SST) is widely used to assess hypothalamic-pituitary-adrenal (HPA) axis in patients on corticosteroids. This requires significant material and human resources especially as patients often require multiple tests. We performed a retrospective cohort study, followed by the implementation of QIP methodology to reduce the number of SST in this cohort of patients.Methodology: We reviewed 167 patients who had a SST and derived ...