Endocrine Abstracts

Background and aims: Bexarotene is the first retinoid receptor X (RXR)-selective agonist approved for cutaneous T-cell lymphoma in patients resistant to at least one previus systemic treatment. However, it produces often two endocrine-metabolic alterations: central hypothyroidism and dyslipidemia. We assessed, in a group of patients with Mycosis Fungoide or Sezary syndrome treated with bexarotene, the endocrine-metabolic side effects.Patients and methods...

Introduction: The demand of health care for people with gender incongruence (IG) has grown exponentially especially in young population. Due to this, there is a growing number of studies that show psychological conflicts and social functioning in those individuals who have not received gender-affirming treatment with medical intervention (pubertal block, hormone or surgical treatment) and social intervention. However, the data published so far do not represent the European cou...

Introduction: PCSK9 inhibitors (iPCSK9) have previously been evaluated through controlled clinical trials showing up to 60% reduction in LDL cholesterol concentrations. However, we still do not have enough data regarding the real life experience of the treatment.Objectives: 1) Describe patients with hypercholesterolemia treated with iPCSK9 in clinical practice.2) Evaluate treatment efficacy and safety.Methods...

Objectives: Obesity and type 2 diabetes mellitus (DM2) are risk factors for non-alcoholic fatty liver disease (NAFLD). The main objective was to study the incidence of NAFLD using the Hepatic Steatosis Index (HSI) in obese patients with DM2. Secondary objectives were to analyse the effect of liraglutide over HSI, body mass index (BMI) and glycated hemoglobin (HbA1c).Methods: Retrospective observational study of obese type 2 diabetic patients treated with...

Objectives and methods: The mechanism that explains the different weight response to various treatments in obese type 2 diabetes (DM2) patients, compared to those without diabetes, is still unknown. In order to establish the weight response to Roux-en-Y Gastric Bypass (RYGB), 268 patients with morbid obesity (IMC 45.4±0.4 kg/m2) were classified by OGTT as having normal glucose tolerance (Grupo A. n=107), prediabetes (Grupo B. n=96) an...

Background: Mid-life obesity is a risk factor for Alzheimer’s disease (AD). On the contrary, late-life obesity has been identified as a protective factor for dementia. Recent published studies have shown that weight loss predicts and precedes dementia diagnosis by decades. Thus, paradoxical effect of body weight across lifespan, the so called “obesity paradox”, might be explained by reverse causality. Structural magnetic resonance imaging (MRI) has been extensiv...

Introduction: Some methodologists have raised concern about the validity of the standard method of assessing patient-reported outcomes, i.e. retrospective questionnaires. Repeated momentary measurements have been introduced to avoid recall bias and provide ecological validity. Although having theoretical advantages, the measurement properties remain unsubstantiated. This study examines the relationship between the retrospective thyroid-related quality of life patient-reported ...

Endocrine disrupting chemicals (EDCs) produce adverse effects associated with numerous pathologies: neurological disorders, metabolic diseases, infertility and cancer for example. How EDCs interfere with the development of hormone-sensitive tissue is a major question in biology. In this study, we propose that the model of prostate organoids can be used to study the effects of EDCs on the development of the prostate gland. Indeed, the differentiation of adult stem cells (ASC) i...

Cardiovascular complications including arrhythmias and cardiac conduction disorders (ACCDs) are leading risk factors for high mortality rate in acromegaly. ACCDs are the main cause of sudden cardiac death in patients with acromegaly. These disorders are detected in up to 40% of patients. Different pathogenetic mechanisms contribute to the development of concentric biventricular myocardium hypertrophy which leads to electrophysiological myocardium feature changes. The goal of t...

BackgroundThe multiple endocrine neoplasia syndrome type 2 (MEN-2) is characterized by medullary thyroid cancer (MTC) as a permanent feature; the combination with pheochromocytoma and parathyroidism is referred as MEN-2a syndrome. The reason for hereditary forms of MTC is mutations in the proto-oncogene RET (RE-arranged during Transfection).The aim of the study was to establish the molecular determinants frequency of MEN-2 syndrome...