Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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Page 6 of about 175 results

ea0099ep1323 | Late Breaking | ECE2024

Quality of life improvement associated with the rechallenge with extended-release metformin in patients with type 2 diabetes labelled as metformin-intolerant

Molinero-Marcos Inmaculada , Hernandez-Lazaro Alba , Jose de Leon-Durango Ricardo , Rios-Gomez Carlos , Santana Ojeda Borja , Kuzior Agnieszka , Arnas-Leon Claudia , Maria Perez-Rivero Jennifer , del Pino Perez-Garcia Maria , Javier Martinez Martin Francisco

Introduction and Objectives: The tolerability of extended-release metformin (XRM) is clearly superior to that of conventional metformin, with the potential to improve patient compliance, effectiveness and outcomes. Since 2005 the NICE guidelines for type 2 diabetes mellitus (T2DM) recommend its use in patients with metformin-caused gastrointestinal disturbances. XRM is recently available in Spain as a fixed combination with sitagliptin, but not in monotherapy. We assessed the ...
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ea0081ep548 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Methods to measure the mitochondrial toxicity in mouse kidney stem cell by toxicant

Lee Minsu , Kim KangMin , Lee Jimin , Kim YongIn , Jeung Eui-Bae

Mitochondria play an important role in generating energy, and they are essential to cell survival. Mitochondria have varieties of functions, such as regulating intracellular calcium concentration and signal transduction, controlling hormone synthesis, inflammatory responses, and free radicals. In particular, this research is interested in the mitochondria in kidney tubular cell. Since mitochondria in tubular cells play an important role in supplying energy, removal of waste an...
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ea0037s22.3 | Beta cell biology | ECE2015

Novel models of human pancreatic beta cells

Ravassard Philippe

Despite intense efforts over the past decades, human pancreatic beta cell lines with physiological insulin secretion have not been available. We have developed a robust transplantation model of fetal human pancreases that recapitulates pancreas development and combined such model with integrative lentiviral-mediated gene transfer. This resulted in production of human transgenic pancreases in which dynamic aspects of development can be studied. We thus forced expression of immo...
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ea0037ew1.4 | Practical publishing advice | ECE2015

Responding to reviewer comments

Romijn Johannes

A statement attributed to Aristotle is: ‘You can easily avoid criticism by saying nothing, doing nothing, and being nothing.’ If you want to do research, apply for competitive grants and publish relevant scientific papers in competitive journals, criticism is a fact of life. There is also a positive twist to criticism: it is a major driving force to advance knowledge in science.Frequently, the first reaction of authors to critical comments of r...
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ea0031s12.3 | Thymic function and autoimmune endocrine disease | SFEBES2013

Thymic microenvironments for T cell repertoire formation

Takahama Yousuke

During the development in the thymus, a virgin repertoire of diverse TCR-αβ recognition specificities in immature T cells is selected through positive and negative selection to form a functionally competent and self-tolerant repertoire of mature T cells. Positive selection supports the survival of self-MHC-restricted thymocytes that receive low-affinity TCR engagement, whereas negative selection deletes potentially harmful self-reactive thymocytes upon high-affinity ...
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ea0029p156 | Bone & Osteoporosis | ICEECE2012

Platinum nanoparticle reduces ovariectomy-induced bone loss by decreasing osteoclastogenesis

Kim W. , Kim J. , Kim J. , Choi H.

Platinum nanoparticles have shown to have a remarkable antioxidant activity. Growing evidence between oxidative stress and bone loss suggests that platinum nanoparticle could protect bone loss via modulating oxidative stress. Intragastrical administration of platinum nanoparticle reduced ovariectomy (OVX)-induced bone loss with lowered level of in vivo bone resorption. Platinum nanoparticle inhibited osteoclast (OC) formation via an impaired receptor activator of nuclea...
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ea0011p386 | Diabetes, metabolism and cardiovascular | ECE2006

The KCNJ11 E23K and UCP2 G-866A SNPs in relation to DM2 in Czech population

Vejrazkova D , Vankova M , Lukasova P , Vcelak J , Kvasnickova H , Vondra K , Bendlova B

KCNJ11 as well as UCP2 genes are involved via modulation of ATP concentration in pancreatic beta-cells in control of insulin secretion. The aim of study was to compare genotypic distribution of E23K (KCNJ11) and G-866A (UCP2) polymorphisms between diabetics, their offspring and controls and to study the possible association of these polymorphisms with biochemical and anthropometric parameters.The study entered 302 diabetics, 165 offspring, 241 controls. ...
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ea0003p91 | Diabetes & Metabolism | BES2002

Thioland and steriod levels in polycystic ovary syndrome

Dvorakova K , Tallova J , Hill M , Vrbikova J

Aim: To investigate total homocysteine (Hcy), cysteine (Cys), glutathione (GSH), lipid and steroid sulfate levels in women with polycystic ovary syndrome (PCOS).Methods: The blood levels of Hcy, Cys, GSH (determined by HPLC), total and HDL-cholesterol, insulin (IRMA),DHEA and DHEAS, cortisol, pregnenolone, 17-hydroxy-pregnenolone and pregnenolone-sulphate (all RIA) were examined in 44 women with PCOS (age 24+/-7yrs) and 12 healthy controls (34+/-5yrs) in...
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ea0056ehm1biog | European Hormone Medal Lecture | ECE2018

European Hormone Medal Lecture

The European Hormone Medal is awarded to an international scientist who has made significant contributions to the field of basic or clinical endocrinology. This year’s recipient is Professor Ilpo Huhtaniemi who will receive his prize and give his lecture as part of the European Congress of Endocrinology (ECE), beginning on the 19 May 2018. Further information on the prize can be found at https://www.ese-horm...
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ea0073ep98 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Novel toxicological method to investigate the increased ROS in mouse kidney stem cell mitochondria by doxorubicin

Lee Minsu , Jeong Sunhwa , Lee Jimin , Yi Donglin , Eui-Bae Jeung

Mitochondria play a key role in hormone biosynthesis and involve in renal cell proliferation by producing about 90% of cellular energy and controlling cell apoptosis. Doxorubicin is commonly used for many tumor treatments. However, its clinical utility is limited by the adverse reactions, which are known to be nephrotoxic. The mechanism by which doxorubicin induced kidney damage is still not completely understood, however nephrotoxicity by doxorubicin might be related to mitoc...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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