Endocrine Abstracts

Introduction: A new subtype of diabetes, ketosis-prone diabetes (KPD) has been described in the last years among African, Asian and Hispanic population with characteristics similar to type 1 diabetes (DM1) such as cardinal symptoms, tendency to ketosis and decreased pancreatic reserve at onset, but with negative autoimmunity. The aim of this study was to compare this type of patients with those with type 1 diabetes at onset and their evolution.Material a...

Aim: Comparing the effect of Faster Aspart insulin (Fiasp®) with previous insulin analogues (aspart, lispro) in type I diabetic patients with sensor-augmented pump therapy.Methods: Patients with Minimed Paradigm® insulin pumps, Enlite® sensors and Guardian® software (able to automatically stop the pump infusion to prevent hypoglycemia) were switched from previous insulin to Faster Aspart. Da...

Introduction/Aim: Transgender people often worry about side effects of their hormonal therapy, including breast cancer, which is an exceedingly rare occurrence. Hereby we present the case of a patient with an uncommon metadiabetic complication that can be easily confused with breast cancer, with the aim of raising awareness on this condition.Material and Methods: Review of the Clinical Record of the patient and of the relevant literature.<p class="ab...

Introduction: Non-functioning pituitary adenomas are relatively common. A large number of these tumors are asintomathic pituitary microadenomas, that are increasingly detected because of sensitive imaging techniques improves. Those tumors that require treatment are generally macroadenomas and come to medical attention because of mass effect (visual field defects, headache, …) and/or hypopituitarism.Objective: To assess non-functioning pituitary ade...

Introduction: Hypophysary aneurysms are rare, they account for 1% to 2% of all intracranial aneurysms (1) and can be mistaken for pituitary adenomas, since they can have similar symptoms and even radiological signs especially if it’s an aneurysm completely thrombosed as angiography will show only avascular mass (2).Clinical case: A 84 year old female with past medical history of hypertension, dyslipidemia and depressive disorder, presents to emergen...

Introduction: Papillary thyroid cancer (PTC) has an excellent prognosis in most cases with a 10-year survival rate of more than 95% but decreases drastically in cases of PTC iodine-refractory, in recurrent and/or metastatic disease. Tyrosine kinase inhibitors, such as lenvatinib or sorafenib, have been approved in such cases and in some cases are able to stabilize the disease and prolong survival. However, serious side effects have been reported such as fistula formation, blee...

Introduction: Myxedema coma is a rare life-threatening clinical condition in patients with longstanding severe untreated hypothyroidism, in whom adaptive mechanisms fail to maintain homeostasis. Most patients, however, are not comatose, and, although strict criteria have been proposed, it is often difficult to differentiate it from very severe hypothyroidism, lacking only a precipitating event.Material and methods: We present the clinical picture of 70 c...

Introduction: Many studies have shown that cigarette smoking exerts multiple effects on the thyroid gland. Smoking seems to induce changes in thyroid function tests, like a left-shift in serum TSH level that is more apparent in iodine-deficient subjects and increase in thyroid hormones. We describe the effect of an intensive thyroxine intravenous treatment in severe hypothyroid patients and the results depending on their smoking status.Material and metho...

Aim: To establish the effect of a supplement containing 250 mg red yeast rice extract, 525 mg berberine and 50 mg coenzyme Q10 on insulin sensitivity in patients with hypercholesterolemia and prediabetes.Methods: For this open, uncontrolled study, patients of age 30–75 years, with hypercholesterolemia (LDL cholesterol >130 mg/dl and triglycerides <300 mg/dl), and prediabetes without overt cardiovascular disease, untreated in the previous 6 m...

Introduction: Pituitary adenomas are considered to be benign tumors that are diagnosed by its sympthoms (secondary to compression or hormonal secretion) or incidentally in an imaging technique performed because of another reason. ‘Silent’ somatotrophinomas are very rare. This type of adenoma is typically large and despite it presents with mild or no acromegalic features it usually develops hormone secretion.A case report: A 29-year-old spanish ...