Endocrine Abstracts

Progression of metabolic syndrome to diabetes is not easily predicted in patients with morbid obesity. We hypothesized that no insulin-resistance is more usual as we thought.Objective: Evaluate prevalence of no insulin-resistance status in patients with morbid obesity.Patients and method: The study was undertaken in 130 patients with a BMI of 53.93±6.67 kg/m2. The morbidly obese patients were divided into four group...

Association between anorexia nerviosa (AN) and low bone mass has been demonstrated. Bone loss associated with AN involve hormonal and nutritional impairments, though their exact contribution is not clearly established. We compare bone mass in AN patients with women of similar weight with no criteria for anorexia nervosa, and a third group of healthy, normal-weight, age-matched women. The study included 48 patients with AN (DSM-IV criteria), 22 healthy eumenorrheic women with l...

Adiponectin and leptin have been described as potential contributors to bone metabolism. The effect of anticatabolic drugs on these adipokines and their relationship with bone metabolism have not been clearly clarified.Aims: (1) Evaluate adiponectin and leptin levels in osteoporosic postmenopausal women and their relationship with BMD, bone turnover and osteoclastogenesis markers. (2) Analyze changes on adiponectin and leptin levels after treatment with ...

Low concentrations of vitamin D leads to secondary hiperparathyroidism, bone loss, and an increase of osteoporotic fractures in populations at risk. Adequate vitamin D and calcium intake is considered an essential component of postmenopausal osteoporosis management. Several epidemiological studies have assessed the prevalence of low serum vitamin D concentrations, indicating that vitamin D inadequacy (<30 ng/ml) is a problem world-wide.Aims: To evalu...

Thiazolidinediones have demonstrated some efficacy in promoting radioiodine uptake of previously poorly radioiodine-responsive thyroid cancers. We describe the effect of rosiglitazone, in promoting uptake in thyroid metastatic tissue with weak uptake in order to treatment with radioiodine in two patients.Case 1: A 62-year-old woman with thyroid cancer and negative I-131 body scan post therapy (150 mCi) with presence of recurrent disease (PET positive in ...

Patients with persistent PHPT after parathyroidectomy (PTX) or contraindications for PTX often require chronic treatment for hypercalcemia, representing an unmet medical need. In an open-label, single-arm study in the US and EU, 17 patients underwent a variable length titration phase (maximum 16 weeks) with a maintenance phase (MP) of up to 3 years. Patients were eligible if they had (1) persistent PHPT following PTX or were considered contraindicated for PTX, and (2) serum ca...

Background: Nadir GH<2 mU/l in OGTT, normal IGF-I and mean GH<5 mU/l in the growth hormone day curve (GHDC) are considered the therapeutic endpoints in patients with acromegaly. However, discrepancies between these parameters have been reported.Aim: To compare the utility of the above tests in assessing the acromegaly status following surgical treatment.Patients and methods: Twenty-six consecutive patients (16 females) diag...

Introduction: Pituitary adenomas causing acromegaly are immunocytochemically divided into 3 main groups: growth hormone (GH) cell (A), those with GH and prolactin (PRL) cell differentiation (B) and plurihormonal (C). Recent large series comparing the hormonal and imaging features of these tumours at diagnosis are lacking.Objectives: To investigate differences in the presenting hormonal and imaging data associated with the above groups of adenomas.<p ...

Purpose: A combined model of clinical, biochemical and radiological variables could help to predict autonomous cortisol secretion (ACS) in adrenal incidentalomas (AI).Methods: We analyzed retrospectively 100 patients diagnosed of AI between 2011 and 2015. AI was defined as an adrenal mass>1 cm, accidentally discovered by radiologic examination. ACS was ruled out (ACS-) by serum cortisol post-dexamethasone suppression test (Nugent) <3 μg/dl, ...

Background: Polycystic ovary syndrome (PCOS) is a common endocrine condition in women at reproductive age, in whom, glucose metabolism disturbances are commonly observed. In addition, overweight and obesity, especially visceral obesity, are more prevalent in PCOS women, which enhances the resistance to insulin action, and as consequence, the onset of impaired glucose tolerance (IGT) and/or type 2 diabetes mellitus (T2DM). Clinical guidelines recommend oral glucose tolerance te...